Matches in SemOpenAlex for { <https://semopenalex.org/work/W2255991844> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2255991844 endingPage "354" @default.
- W2255991844 startingPage "343" @default.
- W2255991844 abstract "Drugs and heavy metals may alter the synthesis of hemo-proteins by either inducing or inhibiting various enzymes in the heme biosynthetic pathway (Fig. 1) (Tephly et al., 1971; Tephly et al., 1973). Porphyrogenic drugs and inducers of the hepatic hemo-protein, cytochrome P-450, such as phenobarbital, induce hepatic δ-aminolevulinic acid synthetase (ALAS), the initial and proposed rate-limiting enzyme of this pathway (Granick and Urata, 1963; Baron and Tephly, 1969; Tephly et al., 1973). Ferrochelatase (heme synthetase, protoheme ferro-lyase, EC 4.99.1.1), the terminal enzyme in the heme pathway, is located on the inner mitochondrial membrane (Jones and Jones, 1968; McKay et al., 1969) and catalyzes the formation of heme from protoporphyrin IX and ferrous iron (Labbe and Hubbard, 1960). This enzyme, like ALAS, is inducible (Hasegawa et al., 1970; Tephly et al., 1971), and may be subject to product inhibition by heme (Jones and Jones, 1970). Heme which is formed through ferrochelatase is then available for synthesis of cytochrome P-450 and other hemoproteins. Tephly and co-workers (Tephly and Hibbeln, 1971; Tephly et al., 1972) have reported that cobalt treatment produces a substantial decrease in the level of hepatic cytochrome P-450." @default.
- W2255991844 created "2016-06-24" @default.
- W2255991844 creator A5002630064 @default.
- W2255991844 creator A5066841598 @default.
- W2255991844 date "1975-01-01" @default.
- W2255991844 modified "2023-10-14" @default.
- W2255991844 title "A Possible Role of Copper in the Regulation of Heme Biosynthesis Through Ferrochelatase" @default.
- W2255991844 cites W120404398 @default.
- W2255991844 cites W1775749144 @default.
- W2255991844 cites W1964479613 @default.
- W2255991844 cites W2000755161 @default.
- W2255991844 cites W2012341697 @default.
- W2255991844 cites W2028013362 @default.
- W2255991844 cites W203009548 @default.
- W2255991844 cites W2068597663 @default.
- W2255991844 cites W2085501553 @default.
- W2255991844 cites W2112007697 @default.
- W2255991844 cites W2131838860 @default.
- W2255991844 cites W2225388783 @default.
- W2255991844 cites W2316773547 @default.
- W2255991844 cites W2412261528 @default.
- W2255991844 cites W575512628 @default.
- W2255991844 doi "https://doi.org/10.1007/978-1-4615-9026-2_24" @default.
- W2255991844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1155252" @default.
- W2255991844 hasPublicationYear "1975" @default.
- W2255991844 type Work @default.
- W2255991844 sameAs 2255991844 @default.
- W2255991844 citedByCount "29" @default.
- W2255991844 countsByYear W22559918442013 @default.
- W2255991844 countsByYear W22559918442015 @default.
- W2255991844 countsByYear W22559918442017 @default.
- W2255991844 countsByYear W22559918442019 @default.
- W2255991844 countsByYear W22559918442020 @default.
- W2255991844 crossrefType "book-chapter" @default.
- W2255991844 hasAuthorship W2255991844A5002630064 @default.
- W2255991844 hasAuthorship W2255991844A5066841598 @default.
- W2255991844 hasConcept C134018914 @default.
- W2255991844 hasConcept C178790620 @default.
- W2255991844 hasConcept C181199279 @default.
- W2255991844 hasConcept C185592680 @default.
- W2255991844 hasConcept C20705724 @default.
- W2255991844 hasConcept C2776217839 @default.
- W2255991844 hasConcept C2777940757 @default.
- W2255991844 hasConcept C2779671804 @default.
- W2255991844 hasConcept C2780768313 @default.
- W2255991844 hasConcept C2781149050 @default.
- W2255991844 hasConcept C2781323092 @default.
- W2255991844 hasConcept C526171541 @default.
- W2255991844 hasConcept C553450214 @default.
- W2255991844 hasConcept C55493867 @default.
- W2255991844 hasConcept C71240020 @default.
- W2255991844 hasConcept C86803240 @default.
- W2255991844 hasConceptScore W2255991844C134018914 @default.
- W2255991844 hasConceptScore W2255991844C178790620 @default.
- W2255991844 hasConceptScore W2255991844C181199279 @default.
- W2255991844 hasConceptScore W2255991844C185592680 @default.
- W2255991844 hasConceptScore W2255991844C20705724 @default.
- W2255991844 hasConceptScore W2255991844C2776217839 @default.
- W2255991844 hasConceptScore W2255991844C2777940757 @default.
- W2255991844 hasConceptScore W2255991844C2779671804 @default.
- W2255991844 hasConceptScore W2255991844C2780768313 @default.
- W2255991844 hasConceptScore W2255991844C2781149050 @default.
- W2255991844 hasConceptScore W2255991844C2781323092 @default.
- W2255991844 hasConceptScore W2255991844C526171541 @default.
- W2255991844 hasConceptScore W2255991844C553450214 @default.
- W2255991844 hasConceptScore W2255991844C55493867 @default.
- W2255991844 hasConceptScore W2255991844C71240020 @default.
- W2255991844 hasConceptScore W2255991844C86803240 @default.
- W2255991844 hasLocation W22559918441 @default.
- W2255991844 hasLocation W22559918442 @default.
- W2255991844 hasOpenAccess W2255991844 @default.
- W2255991844 hasPrimaryLocation W22559918441 @default.
- W2255991844 hasRelatedWork W1714394214 @default.
- W2255991844 hasRelatedWork W2020348103 @default.
- W2255991844 hasRelatedWork W2037761468 @default.
- W2255991844 hasRelatedWork W2044318015 @default.
- W2255991844 hasRelatedWork W2044935454 @default.
- W2255991844 hasRelatedWork W2083765055 @default.
- W2255991844 hasRelatedWork W2164127567 @default.
- W2255991844 hasRelatedWork W2403954667 @default.
- W2255991844 hasRelatedWork W2495301844 @default.
- W2255991844 hasRelatedWork W4310603550 @default.
- W2255991844 isParatext "false" @default.
- W2255991844 isRetracted "false" @default.
- W2255991844 magId "2255991844" @default.
- W2255991844 workType "book-chapter" @default.