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- W2256050882 abstract "ABSTRACT IgG antibodies to Plasmodium falciparum are transferred from the maternal to fetal circulation during pregnancy, wane after birth, and are subsequently acquired in response to natural infection. We examined the dynamics of malaria antibody responses of 84 Kenyan infants from birth to 36 months of age by (i) serology, (ii) variant surface antigen (VSA) assay, (iii) growth inhibitory activity (GIA), and (iv) invasion inhibition assays (IIA) specific for merozoite surface protein 1 (MSP1) and sialic acid-dependent invasion pathway. Maternal antibodies in each of these four categories were detected in cord blood and decreased to their lowest level by approximately 6 months of age. Serologic antibodies to 3 preerythrocytic and 10 blood-stage antigens subsequently increased, reaching peak prevalence by 36 months. In contrast, antibodies measured by VSA, GIA, and IIA remained low even up to 36 months. Infants sensitized to P. falciparum in utero , defined by cord blood lymphocyte recall responses to malaria antigens, acquired antimalarial antibodies at the same rate as those who were not sensitized in utero , indicating that fetal exposure to malaria antigens did not affect subsequent infant antimalarial responses. Infants with detectable serologic antibodies at 12 months of age had an increased risk of P. falciparum infection during the subsequent 24 months. We conclude that serologic measures of antimalarial antibodies in children 36 months of age or younger represent biomarkers of malaria exposure rather than protection and that functional antibodies develop after 36 months of age in this population." @default.
- W2256050882 created "2016-06-24" @default.
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- W2256050882 date "2016-02-01" @default.
- W2256050882 modified "2023-10-16" @default.
- W2256050882 title "Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort" @default.
- W2256050882 cites W1557705664 @default.
- W2256050882 cites W1596563064 @default.
- W2256050882 cites W1660800855 @default.
- W2256050882 cites W1964149115 @default.
- W2256050882 cites W1966867282 @default.
- W2256050882 cites W1966926581 @default.
- W2256050882 cites W1967015536 @default.
- W2256050882 cites W1971941909 @default.
- W2256050882 cites W1973077293 @default.
- W2256050882 cites W1974074965 @default.
- W2256050882 cites W1977086234 @default.
- W2256050882 cites W1981376031 @default.
- W2256050882 cites W1984303903 @default.
- W2256050882 cites W1986400970 @default.
- W2256050882 cites W1987984230 @default.
- W2256050882 cites W1988327885 @default.
- W2256050882 cites W1999647461 @default.
- W2256050882 cites W2000552640 @default.
- W2256050882 cites W2004646638 @default.
- W2256050882 cites W2004896101 @default.
- W2256050882 cites W2010748776 @default.
- W2256050882 cites W2011349326 @default.
- W2256050882 cites W2012593576 @default.
- W2256050882 cites W2015501528 @default.
- W2256050882 cites W2016746408 @default.
- W2256050882 cites W2020055018 @default.
- W2256050882 cites W2029393322 @default.
- W2256050882 cites W2035169581 @default.
- W2256050882 cites W2036558143 @default.
- W2256050882 cites W2036875255 @default.
- W2256050882 cites W2037527898 @default.
- W2256050882 cites W2043330521 @default.
- W2256050882 cites W2055325790 @default.
- W2256050882 cites W2059025191 @default.
- W2256050882 cites W2063283618 @default.
- W2256050882 cites W2069460651 @default.
- W2256050882 cites W2073748354 @default.
- W2256050882 cites W2074647514 @default.
- W2256050882 cites W2077011598 @default.
- W2256050882 cites W2079364750 @default.
- W2256050882 cites W2083426991 @default.
- W2256050882 cites W2083442176 @default.
- W2256050882 cites W2086606486 @default.
- W2256050882 cites W2089686634 @default.
- W2256050882 cites W2091354877 @default.
- W2256050882 cites W2097193246 @default.
- W2256050882 cites W2097352333 @default.
- W2256050882 cites W2098671941 @default.
- W2256050882 cites W2099865725 @default.
- W2256050882 cites W2104827294 @default.
- W2256050882 cites W2109205591 @default.
- W2256050882 cites W2110636054 @default.
- W2256050882 cites W2110876580 @default.
- W2256050882 cites W2113251371 @default.
- W2256050882 cites W2115150674 @default.
- W2256050882 cites W2115786726 @default.
- W2256050882 cites W2116105269 @default.
- W2256050882 cites W2116949436 @default.
- W2256050882 cites W2117132127 @default.
- W2256050882 cites W2120038281 @default.
- W2256050882 cites W2121437137 @default.
- W2256050882 cites W2122070396 @default.
- W2256050882 cites W2123770466 @default.
- W2256050882 cites W2123874102 @default.
- W2256050882 cites W2125326441 @default.
- W2256050882 cites W2126924775 @default.
- W2256050882 cites W2127166169 @default.
- W2256050882 cites W2127773720 @default.
- W2256050882 cites W2128319492 @default.
- W2256050882 cites W2129316783 @default.
- W2256050882 cites W2136559579 @default.
- W2256050882 cites W2136816055 @default.
- W2256050882 cites W2137512223 @default.