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- W2256066116 endingPage "e62" @default.
- W2256066116 startingPage "e62" @default.
- W2256066116 abstract "Macrophages have central roles in danger detection, inflammation and host defense, and consequently, these cells are intimately linked to most disease processes. Major advances in our understanding of the development and function of macrophages have recently come to light. For example, it is now clear that tissue-resident macrophages can be derived from either blood monocytes or through local proliferation of phagocytes that are originally seeded during embryonic development. Metabolic state has also emerged as a major control point for macrophage activation phenotypes. Herein, we review recent literature linking the histone deacetylase (HDAC) family of enzymes to macrophage development and activation, particularly in relation to these recent developments. There has been considerable interest in potential therapeutic applications for small molecule inhibitors of HDACs (HDACi), not only for cancer, but also for inflammatory and infectious diseases. However, the enormous range of molecular and cellular processes that are controlled by different HDAC enzymes presents a potential stumbling block to clinical development. We therefore present examples of how classical HDACs control macrophage functions, roles of specific HDACs in these processes and approaches for selective targeting of drugs, such as HDACi, to macrophages. Development of selective inhibitors of macrophage-expressed HDACs and/or selective delivery of pan HDACi to macrophages may provide avenues for enhancing efficacy of HDACi in therapeutic applications, while limiting unwanted side effects." @default.
- W2256066116 created "2016-06-24" @default.
- W2256066116 creator A5013307192 @default.
- W2256066116 creator A5026924357 @default.
- W2256066116 creator A5053439487 @default.
- W2256066116 creator A5063280122 @default.
- W2256066116 creator A5089626613 @default.
- W2256066116 date "2016-01-29" @default.
- W2256066116 modified "2023-10-11" @default.
- W2256066116 title "Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases" @default.
- W2256066116 cites W1171241794 @default.
- W2256066116 cites W1484277267 @default.
- W2256066116 cites W1544249031 @default.
- W2256066116 cites W1548584275 @default.
- W2256066116 cites W1553155385 @default.
- W2256066116 cites W1554748704 @default.
- W2256066116 cites W1583504016 @default.
- W2256066116 cites W1588611448 @default.
- W2256066116 cites W1646217211 @default.
- W2256066116 cites W1812570211 @default.
- W2256066116 cites W1828418245 @default.
- W2256066116 cites W1952769153 @default.
- W2256066116 cites W1968314562 @default.
- W2256066116 cites W1968482791 @default.
- W2256066116 cites W1970629672 @default.
- W2256066116 cites W1971112771 @default.
- W2256066116 cites W1971621147 @default.
- W2256066116 cites W1976699241 @default.
- W2256066116 cites W1976933461 @default.
- W2256066116 cites W1977536320 @default.
- W2256066116 cites W1978679896 @default.
- W2256066116 cites W1979610433 @default.
- W2256066116 cites W1980654946 @default.
- W2256066116 cites W1983802532 @default.
- W2256066116 cites W1984061476 @default.
- W2256066116 cites W1985651059 @default.
- W2256066116 cites W1985845937 @default.
- W2256066116 cites W1985859986 @default.
- W2256066116 cites W1991442992 @default.
- W2256066116 cites W1997423398 @default.
- W2256066116 cites W1998324306 @default.
- W2256066116 cites W1999952543 @default.
- W2256066116 cites W2007139310 @default.
- W2256066116 cites W2010876644 @default.
- W2256066116 cites W2013051750 @default.
- W2256066116 cites W2013598984 @default.
- W2256066116 cites W2018342311 @default.
- W2256066116 cites W2018613239 @default.
- W2256066116 cites W2023351948 @default.
- W2256066116 cites W2024940496 @default.
- W2256066116 cites W2029130907 @default.
- W2256066116 cites W2031603575 @default.
- W2256066116 cites W2035178142 @default.
- W2256066116 cites W2035584686 @default.
- W2256066116 cites W2037630087 @default.
- W2256066116 cites W2039568759 @default.
- W2256066116 cites W2042597829 @default.
- W2256066116 cites W2043388746 @default.
- W2256066116 cites W2046345187 @default.
- W2256066116 cites W2047563937 @default.
- W2256066116 cites W2048481788 @default.
- W2256066116 cites W2050941712 @default.
- W2256066116 cites W2052373759 @default.
- W2256066116 cites W2055074685 @default.
- W2256066116 cites W2056564149 @default.
- W2256066116 cites W2063680739 @default.
- W2256066116 cites W2064437293 @default.
- W2256066116 cites W2066077385 @default.
- W2256066116 cites W2066361290 @default.
- W2256066116 cites W2066887945 @default.
- W2256066116 cites W2066988410 @default.
- W2256066116 cites W2072392441 @default.
- W2256066116 cites W2072769860 @default.
- W2256066116 cites W2074006690 @default.
- W2256066116 cites W2076272449 @default.
- W2256066116 cites W2079082252 @default.
- W2256066116 cites W2087143957 @default.
- W2256066116 cites W2087714970 @default.
- W2256066116 cites W2089532303 @default.
- W2256066116 cites W2089668600 @default.
- W2256066116 cites W2096406449 @default.
- W2256066116 cites W2098954540 @default.
- W2256066116 cites W2099792852 @default.
- W2256066116 cites W2105152492 @default.
- W2256066116 cites W2106227592 @default.
- W2256066116 cites W2109920062 @default.
- W2256066116 cites W2110712205 @default.
- W2256066116 cites W2112042684 @default.
- W2256066116 cites W2114231153 @default.
- W2256066116 cites W2114553667 @default.
- W2256066116 cites W2114668694 @default.
- W2256066116 cites W2117096101 @default.
- W2256066116 cites W2120281059 @default.
- W2256066116 cites W2120562230 @default.
- W2256066116 cites W2123383613 @default.
- W2256066116 cites W2124841332 @default.
- W2256066116 cites W2132682917 @default.
- W2256066116 cites W2137659055 @default.