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- W2256141566 abstract "Preventing prescription opioid poisoning deaths is a major public health priority in Western societies. Deaths from these medications exceed deaths from all illicit drugs combined [1]. Methadone (for pain treatment) is involved in one third of US prescription opioid overdose deaths despite accounting for only 5% of dispensed opioids [2]. There is a dose-dependent increase in the severity of central sleep apnoea (CSA) with methadone [3–5] and sleep disordered breathing is a contributing factor in methadone-related deaths [2]. The partial μ-agonist buprenorphine is putatively safer than methadone with a ceiling effect upon respiratory depression [6]. However, the effect of buprenorphine on breathing during sleep remains unclear. The only relevant report from a cross-sectional observational study suggested that buprenorphine-naloxone therapy may induce significant CSA and hypoxaemia [7]. Methadone-using patients with central sleep apnoea may reverse symptoms with switch to buprenorphine-naloxone therapy <http://ow.ly/NilUq>" @default.
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- W2256141566 date "2015-06-25" @default.
- W2256141566 modified "2023-10-14" @default.
- W2256141566 title "Reversal of central sleep apnoea with change from methadone to buprenorphine-naloxone: a case report" @default.
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- W2256141566 doi "https://doi.org/10.1183/09031936.00051315" @default.
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