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- W2256227318 abstract "Objective To study the in vivo and in vitro effect of ornidazole,ornidazole gel and ornidazole suppository on Trichomonas vaginalis.Methods In the in vivo study,Trichomonas vaginalis and various concentrations of drugs(ornidazole gel,ornidazole or ornidazole suppository) were injected into the vagina of mice.Surviving protozoans in the vaginal lavage fluid were examined at the second day after last injection.In the in vitro experiment,Trichomonas vaginalis was incubated in wells of microplate with various concentrations of ornidazole gel,ornidazole,and ornidazole suppository.The morphological change of parasite was observed under an invert microscope and the death rate was calculated after different incubation time.Results The growth of parasites in mice with 5 days ornidazole,ornidazole gel and ornidazole suppository treatments were all negative(0/20),while the control group was 100% positive(20/20)(P0.01).In the in vitro experiment,after 24 h of incubation,the minimum concentration killing 100% of the testing protozoan was 0.0025 mg/ml for the ornidazole gel,0.0049 mg/ml for ornidazole,and 0.0195 mg/ml for the ornidazole suppositor.Conclusion Ornidazole gel is more effective than ornidazole suppository in the killing of Trichomonas vaginalis." @default.
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- W2256227318 date "2010-01-01" @default.
- W2256227318 modified "2023-09-25" @default.
- W2256227318 title "Efficacy of different forms of ornidazole on Trichomonas vaginalis." @default.
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