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- W2256278280 abstract "Methods: Retrospective review of patients with bronchiectasis with Pseudomonas aeruginosa (PA) isolated from sputum at least twice during the year prior to nebulized antibiotic (NA) onset and a minimum 6-month follow-up. Results: 17 patients included (9 men), median age 69.7 yrs, average follow-up 753 days (183-1824). Nine patients received more than 1 NA during follow-up (31 NA courses in total): 16 colistin, 14 tobramycin, 1 gentamicin. Average treatment duration: 492.5 days (100-971). Subjective improvement was referred by 12 patients (70.5%). Eradication of PA was achieved in 7 (41.2%), but 1 relapse occurred. 8 patients presented side effects at any time during NA (47%), mainly bronchospasm. Table 1 shows a reduction in mean number of admissions/year and mean days of admission/year for all patients. A statistically significant reduction is observed when PA was eradicated. Conclusions: 1. NA resulted in clinical improvement in 70.5% of cases and in eradication of PA in 41.2%. Side effects were observed in 47% of cases. 2. NA reduced number and days of admissions in all patients. A statistically significant reduction was observed if PA was erradicated in whom NA prevented nearly 2 admissions/year." @default.
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- W2256278280 date "2011-09-01" @default.
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- W2256278280 title "Nebulized antibiotics in patients with non-cystic fibrosis bronchiectasis ans chronic pseudomonas aeruginosa infection" @default.
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