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• W2256477671 abstract "Heat shock-mediated delayed protection against myocardial and cerebral ischemia has been attributed to induction of heat shock proteins (HSP), especially HSP70, in myocytes and neurons. However, heat shock preconditioning only induces HSP70 in endothelium. The purpose of this study was to examine the effect of heat shock on endothelium-dependent vasomotor tone. Isolated mouse aortas were heated to 43.5oC for 15 min and returned to 37oC for 18 h. They were then mounted in a wire myograph to assess vasomotor responses to vasoconstrictors and vasodilatators. Intact heat shocked aortas showed reduction in phenylephrineor 5-hydroxytryptamine-induced vasoconstriction, while no difference in vascular reactivity was detected in heat shocked endothelium-denuded aortas. Reduced vasoconstriction in heat shocked aortas was restored to control level by incubation with L-NAME, a nitric oxide synthase (NOS) inhibitor, but not by geldanamycin, a HSP90 inhibitor. Furthermore, the effect of heat shock was not observed in aortas from eNOS null mice, suggesting that vasomotor responsiveness reduced by heat shock was related to increased basal eNOS activity. Immunoblot of lysates from heat shocked aortas did not show upregulation of eNOS or other NOS isoforms, while showing robust expression of HSP70; immunoprecipitation using eNOS polyclonal or monoclonal antibodies demonstrated HSP70 interaction with eNOS after heat shock. In enzymatic assay Tel 39-095-7384085, Fax 39-095-7384228, E-mail: salomone@unict.it Salvatore Salomone and Jean-Christophe Plumier 2 (conversion of L-arginine to L-citrulline), HSP70 increased enzymatic activity of recombinant eNOS. We conclude that heat shock decreases vasomotor responses to vasoconstrictors by enhancing eNOS basal activity, through interaction with HSP70, that is robustly induced. Such an increase of eNOS might be related to protective effect of heat shock against ischemia reported in vivo. Finally, interaction between HSP70 and eNOS opens the intriguing possibility that HSP70 could have vasoregulatory properties in addition to its cytoprotective functions." @default.
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• W2256477671 date "2011-01-01" @default.
• W2256477671 modified "2023-09-23" @default.
• W2256477671 title "Endothelium-Dependent Effects of Heat Shock on Vasomotor Tone: Role of eNOS and HSP70" @default.
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