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- W2256560479 endingPage "770" @default.
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- W2256560479 abstract "The endocrine pancreas is critically important in the regulation of energy metabolism, with defective insulin secretion from pancreatic islet β-cells a major contributing factor to the development of type 2 diabetes. Small ubiquitin-like modifier (SUMO) proteins have been demonstrated to covalently modify a wide range of target proteins, mediating a broad range of cellular processes. While the effects of SUMOylation on β-cell gene transcription have been previously reviewed, recent reports indicate roles for SUMO outside of the nucleus. In this review we shall focus on the reported non-nuclear roles of SUMOylation in the regulation of β-cells, including SUMOylation as a novel signaling pathway in the acute regulation of insulin secretion." @default.
- W2256560479 created "2016-06-24" @default.
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- W2256560479 date "2012-06-01" @default.
- W2256560479 modified "2023-10-09" @default.
- W2256560479 title "Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus" @default.
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- W2256560479 doi "https://doi.org/10.1139/y11-134" @default.
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