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• W2256618014 abstract "Type I interferons (IFNs) exhibit broad-spectrum antiviral activity, with potential utility against emerging acute virus infections that pose a threat to global health. Recombinant IFN-αs that have been approved for clinical use require cold storage and are administered through intramuscular or subcutaneous injection, features that are problematic for global distribution, storage, and administration. Cognizant that the biological potency of an IFN-α subtype is determined by its binding affinity to the type I IFN receptor, IFNAR, we identified a panel of small molecule nonpeptide compounds using an in silico screening strategy that incorporated specific structural features of amino acids in the receptor-binding domains of the most potent IFN-α, IFN alfacon-1. Hit compounds were selected based on ease of synthesis and formulation properties. In preliminary biological assays, we provide evidence that these compounds exhibit antiviral activity. This proof-of-concept study validates the strategy of in silico design and development for IFN mimetics." @default.
• W2256618014 created "2016-06-24" @default.
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• W2256618014 date "2016-03-01" @default.
• W2256618014 modified "2023-09-27" @default.
• W2256618014 title "Small Molecule Agonists for the Type I Interferon Receptor: An In Silico Approach" @default.
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• W2256618014 doi "https://doi.org/10.1089/jir.2015.0123" @default.
• W2256618014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26700737" @default.
• W2256618014 hasPublicationYear "2016" @default.
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