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- W2256634625 abstract "It is generally believed that sphingomyelin- and cholesterol-enriched microdomains can be isolated as detergent-resistant membranes (DRMs) from plasma membrane and organelle membranes. Here the isolation of microdomains from porcine cardiac sarcoplasmic reticulum (SR) membranes is described. These SR-derived detergent-resistant membranes (SR-DRMs) enriched in sphingomyelin and cholesterol have a low buoyant density. Both ganglioside GM1 and caveolin-3 in the SR. known as a marker protein of caveolae at plasma membrane are present in the SR-DRMs. It was demonstrated that significant amount of SERCAs together with caveolin-3 associates with SR-DRMs, and are fully functional. The results suggested that SR membranes like other biomembranes, such as the plasma membrane, contained microdomains." @default.
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- W2256634625 date "2006-09-01" @default.
- W2256634625 modified "2023-09-25" @default.
- W2256634625 title "Detergent Resistant Microdomains at Cardiac Sarcoplasmic Reticulum Membranes" @default.
- W2256634625 hasPublicationYear "2006" @default.
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