Matches in SemOpenAlex for { <https://semopenalex.org/work/W2256643151> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2256643151 endingPage "685" @default.
- W2256643151 startingPage "676" @default.
- W2256643151 abstract "Oxytetracycline (OTC) production by Streptomyces rimosus was studied in batch and fed-batch cultures in shake flask and bioreactor levels using semi-defined medium. First, the effect of glucose concentration on OTC production and growth kinetics was studied intensively. The optimal glucose concentration in the medium was 15 g/L. Higher glucose concentrations supported higher biomass production by less volumetric and specific antibiotic production. Based on these data, cultivations were carried out at semi-industrial scale 15 L bioreactor in batch culture. At bioreactor level, cell growth and OTC production were higher compared to the shake flask culture by about 18 and 38%, respectively. During the bioreactor cultivation, glucose was totally consumed after only 48 h. Thus, the fed-batch experiment was designed for mono-glucose feeding and complete medium feeding to increase the OTC production by overcoming carbon limitations. The results showed that the fed-batch culture using constant glucose feeding strategy with rate of 0.33 g/L/h produced 1072 mg/L. On the other hand, feeding with complete medium resulted in 45% higher biomass but less OTC production by about 26% compared to mono-glucose fed culture. A further improvement in this process was achieved in by keeping the dissolved oxygen (DO) value at 60% saturation by cascading the glucose feeding pump with the DO controller. The later feeding strategy resulted in higher antibiotic production, reaching 1414 mg/L after 108 h." @default.
- W2256643151 created "2016-06-24" @default.
- W2256643151 creator A5001020039 @default.
- W2256643151 creator A5038893282 @default.
- W2256643151 creator A5066897205 @default.
- W2256643151 date "2015-10-01" @default.
- W2256643151 modified "2023-10-12" @default.
- W2256643151 title "Development of Fed-Batch Cultivation Strategy for Efficient Oxytetracycline Production by Streptomyces rimosus at Semi-Industrial Scale" @default.
- W2256643151 cites W1529095816 @default.
- W2256643151 cites W1964182783 @default.
- W2256643151 cites W1972054291 @default.
- W2256643151 cites W1972793267 @default.
- W2256643151 cites W1974505306 @default.
- W2256643151 cites W1980595016 @default.
- W2256643151 cites W2002051138 @default.
- W2256643151 cites W2005765580 @default.
- W2256643151 cites W2012599065 @default.
- W2256643151 cites W2027571754 @default.
- W2256643151 cites W2032999482 @default.
- W2256643151 cites W2038833328 @default.
- W2256643151 cites W2041146407 @default.
- W2256643151 cites W2046443350 @default.
- W2256643151 cites W2052567477 @default.
- W2256643151 cites W2052968366 @default.
- W2256643151 cites W2054819100 @default.
- W2256643151 cites W2061588341 @default.
- W2256643151 cites W2063792424 @default.
- W2256643151 cites W2066034958 @default.
- W2256643151 cites W2069663710 @default.
- W2256643151 cites W2082900559 @default.
- W2256643151 cites W2085557799 @default.
- W2256643151 cites W2116842045 @default.
- W2256643151 cites W2121966831 @default.
- W2256643151 cites W2298905757 @default.
- W2256643151 cites W264310991 @default.
- W2256643151 doi "https://doi.org/10.1590/s1516-89132015050184" @default.
- W2256643151 hasPublicationYear "2015" @default.
- W2256643151 type Work @default.
- W2256643151 sameAs 2256643151 @default.
- W2256643151 citedByCount "15" @default.
- W2256643151 countsByYear W22566431512016 @default.
- W2256643151 countsByYear W22566431512018 @default.
- W2256643151 countsByYear W22566431512019 @default.
- W2256643151 countsByYear W22566431512020 @default.
- W2256643151 countsByYear W22566431512021 @default.
- W2256643151 countsByYear W22566431512022 @default.
- W2256643151 countsByYear W22566431512023 @default.
- W2256643151 crossrefType "journal-article" @default.
- W2256643151 hasAuthorship W2256643151A5001020039 @default.
- W2256643151 hasAuthorship W2256643151A5038893282 @default.
- W2256643151 hasAuthorship W2256643151A5066897205 @default.
- W2256643151 hasBestOaLocation W22566431511 @default.
- W2256643151 hasConcept C100544194 @default.
- W2256643151 hasConcept C115540264 @default.
- W2256643151 hasConcept C167431671 @default.
- W2256643151 hasConcept C168170006 @default.
- W2256643151 hasConcept C178790620 @default.
- W2256643151 hasConcept C185592680 @default.
- W2256643151 hasConcept C2776671240 @default.
- W2256643151 hasConcept C31903555 @default.
- W2256643151 hasConcept C501593827 @default.
- W2256643151 hasConcept C55493867 @default.
- W2256643151 hasConcept C6557445 @default.
- W2256643151 hasConcept C86803240 @default.
- W2256643151 hasConceptScore W2256643151C100544194 @default.
- W2256643151 hasConceptScore W2256643151C115540264 @default.
- W2256643151 hasConceptScore W2256643151C167431671 @default.
- W2256643151 hasConceptScore W2256643151C168170006 @default.
- W2256643151 hasConceptScore W2256643151C178790620 @default.
- W2256643151 hasConceptScore W2256643151C185592680 @default.
- W2256643151 hasConceptScore W2256643151C2776671240 @default.
- W2256643151 hasConceptScore W2256643151C31903555 @default.
- W2256643151 hasConceptScore W2256643151C501593827 @default.
- W2256643151 hasConceptScore W2256643151C55493867 @default.
- W2256643151 hasConceptScore W2256643151C6557445 @default.
- W2256643151 hasConceptScore W2256643151C86803240 @default.
- W2256643151 hasIssue "5" @default.
- W2256643151 hasLocation W22566431511 @default.
- W2256643151 hasLocation W22566431512 @default.
- W2256643151 hasOpenAccess W2256643151 @default.
- W2256643151 hasPrimaryLocation W22566431511 @default.
- W2256643151 hasRelatedWork W1971881372 @default.
- W2256643151 hasRelatedWork W1975413760 @default.
- W2256643151 hasRelatedWork W1980157704 @default.
- W2256643151 hasRelatedWork W2042287988 @default.
- W2256643151 hasRelatedWork W2051993328 @default.
- W2256643151 hasRelatedWork W2063339262 @default.
- W2256643151 hasRelatedWork W2164200780 @default.
- W2256643151 hasRelatedWork W2168329206 @default.
- W2256643151 hasRelatedWork W2216420124 @default.
- W2256643151 hasRelatedWork W2512696583 @default.
- W2256643151 hasVolume "58" @default.
- W2256643151 isParatext "false" @default.
- W2256643151 isRetracted "false" @default.
- W2256643151 magId "2256643151" @default.
- W2256643151 workType "article" @default.