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- W2256705087 abstract "Significance Bacteria can produce β-lactamases, enzymes that destroy β-lactam antibiotics and thereby resist these potent antibiotics that target cell wall synthesis. Production of β-lactamases is often controlled by β-lactam-induced perturbations in the cell wall. Here, we have identified a new mechanism controlling β-lactamase production. We found a signaling system in which a membrane-associated histidine kinase directly binds β-lactams, triggering the expression of a β-lactamase and resistance to β-lactam antibiotics. Direct sensing of β-lactam antibiotics may enable sufficiently rapid induction of β-lactamase to degrade β-lactam antibiotics before the integrity of the cell wall is disturbed." @default.
- W2256705087 created "2016-06-24" @default.
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- W2256705087 date "2016-02-01" @default.
- W2256705087 modified "2023-10-11" @default.
- W2256705087 title "Sensor histidine kinase is a β-lactam receptor and induces resistance to β-lactam antibiotics" @default.
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- W2256705087 doi "https://doi.org/10.1073/pnas.1520300113" @default.
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