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• W2256932513 startingPage "60" @default.
• W2256932513 abstract "Slow-binding inhibition (SBI) of enzymes is characterized by slow establishment of enzyme-inhibitor equilibrium. Cholinesterases (ChEs) display slow onset of inhibition with certain inhibitors. After a survey of SBI mechanisms, SBI of ChEs is examined. SBI results either from simple slow interaction, induced-fit, or slow conformational selection. In some cases, the slow equilibrium is followed by an irreversible chemical step. This later was observed for the interaction of ChEs with certain irreversible inhibitors. Because slow-binding inhibitors present pharmacological advantages over classical reversible inhibitors (e.g. long target-residence times, resulting in prolonged efficacy with minimal unwanted side effects), slow-binding inhibitors of ChEs are promising new drugs for treatment of Alzheimer disease, myasthenia, and neuroprotection. SBI is also of toxicological importance; it may play a role in mechanisms of resistance and protection against poisoning by irreversible agents." @default.
• W2256932513 created "2016-06-24" @default.
• W2256932513 creator A5015709474 @default.
• W2256932513 creator A5079521426 @default.
• W2256932513 date "2016-03-01" @default.
• W2256932513 modified "2023-09-29" @default.
• W2256932513 title "Slow-binding inhibition of cholinesterases, pharmacological and toxicological relevance" @default.
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• W2256932513 doi "https://doi.org/10.1016/j.abb.2016.02.010" @default.
• W2256932513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26874196" @default.
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