FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2257182834> ?p ?o ?g. }

• W2257182834 endingPage "141" @default.
• W2257182834 startingPage "135" @default.
• W2257182834 abstract "Abstract Human papillomavirus (HPV) is responsible for increasing incidence of oropharyngeal cancer. At present, there are no biomarkers in the surveillance algorithm for HPV-positive oropharyngeal cancer (HPV-OPC). HPV16 E6 antibody precedes oropharyngeal cancer diagnosis. If HPV16 E6 indeed precedes primary diagnosis, it is similarly expected to precede disease recurrence and may have a potential role as a biomarker for surveillance of HPV-OPC. To determine whether HPV antibody titers have a potential role as early markers of disease recurrence or prognosis, a retrospective pilot study was designed to determine whether HPV16 early antibody titers E6, E7, E1, and E2 decrease after treatment of HPV16-positive OPC. Trends in pretreatment, early (≤6 months after treatment), and late posttreatment (&gt;6 months after treatment) HPV16 antibody titers were examined. There were 43, 34, and 52 subjects with serum samples available for pretreatment, early, and late posttreatment intervals. Mean pretreatment antibody levels were higher than posttreatment antibody levels. Average antibody levels decreased significantly over time for E6 (Ptrend = 0.001) and E7 (Ptrend &lt; 0.001). Six disease recurrences were observed during the follow-up period (median, 4.4 years). In univariate analysis, a log-unit increase in pretreatment E6 titer was significantly associated with increased risk of disease recurrence (HR, 5.42; 95% CI, 1.1–25.7; P = 0.03). Therefore, levels of antibodies to HPV16 early oncoproteins decline after therapy. Higher E6 titers at diagnosis are associated with significant increases in the risk of recurrence. These data support the prospective evaluation of HPV16 antibodies as markers of surveillance and for risk stratification at diagnosis. Cancer Prev Res; 9(2); 135–41. ©2015 AACR." @default.
• W2257182834 created "2016-06-24" @default.
• W2257182834 creator A5002679236 @default.
• W2257182834 creator A5016127308 @default.
• W2257182834 creator A5017600358 @default.
• W2257182834 creator A5024057833 @default.
• W2257182834 creator A5030583876 @default.
• W2257182834 creator A5033853754 @default.
• W2257182834 creator A5044599092 @default.
• W2257182834 creator A5052817116 @default.
• W2257182834 creator A5053487762 @default.
• W2257182834 creator A5066909750 @default.
• W2257182834 creator A5071072947 @default.
• W2257182834 creator A5077558876 @default.
• W2257182834 date "2016-02-01" @default.
• W2257182834 modified "2023-09-28" @default.
• W2257182834 title "Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer" @default.
• W2257182834 cites W1522875484 @default.
• W2257182834 cites W1581590351 @default.
• W2257182834 cites W1608565287 @default.
• W2257182834 cites W1686998336 @default.
• W2257182834 cites W1837609262 @default.
• W2257182834 cites W1841898088 @default.
• W2257182834 cites W1968443594 @default.
• W2257182834 cites W2065164105 @default.
• W2257182834 cites W2073911927 @default.
• W2257182834 cites W2082894170 @default.
• W2257182834 cites W2087750771 @default.
• W2257182834 cites W2110664940 @default.
• W2257182834 cites W2115945191 @default.
• W2257182834 cites W2117286343 @default.
• W2257182834 cites W2118441422 @default.
• W2257182834 cites W2124196792 @default.
• W2257182834 cites W2124555997 @default.
• W2257182834 cites W2127605299 @default.
• W2257182834 cites W2132239791 @default.
• W2257182834 cites W2133539678 @default.
• W2257182834 cites W2135034749 @default.
• W2257182834 cites W2141274038 @default.
• W2257182834 cites W2143680521 @default.
• W2257182834 cites W2148344434 @default.
• W2257182834 cites W2151269016 @default.
• W2257182834 cites W2154809117 @default.
• W2257182834 cites W2168041710 @default.
• W2257182834 cites W2917561766 @default.
• W2257182834 cites W3148747298 @default.
• W2257182834 cites W4300161891 @default.
• W2257182834 doi "https://doi.org/10.1158/1940-6207.capr-15-0299" @default.
• W2257182834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4811031" @default.
• W2257182834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26701665" @default.
• W2257182834 hasPublicationYear "2016" @default.
• W2257182834 type Work @default.
• W2257182834 sameAs 2257182834 @default.
• W2257182834 citedByCount "39" @default.
• W2257182834 countsByYear W22571828342017 @default.
• W2257182834 countsByYear W22571828342018 @default.
• W2257182834 countsByYear W22571828342019 @default.
• W2257182834 countsByYear W22571828342020 @default.
• W2257182834 countsByYear W22571828342021 @default.
• W2257182834 countsByYear W22571828342022 @default.
• W2257182834 countsByYear W22571828342023 @default.
• W2257182834 crossrefType "journal-article" @default.
• W2257182834 hasAuthorship W2257182834A5002679236 @default.
• W2257182834 hasAuthorship W2257182834A5016127308 @default.
• W2257182834 hasAuthorship W2257182834A5017600358 @default.
• W2257182834 hasAuthorship W2257182834A5024057833 @default.
• W2257182834 hasAuthorship W2257182834A5030583876 @default.
• W2257182834 hasAuthorship W2257182834A5033853754 @default.
• W2257182834 hasAuthorship W2257182834A5044599092 @default.
• W2257182834 hasAuthorship W2257182834A5052817116 @default.
• W2257182834 hasAuthorship W2257182834A5053487762 @default.
• W2257182834 hasAuthorship W2257182834A5066909750 @default.
• W2257182834 hasAuthorship W2257182834A5071072947 @default.
• W2257182834 hasAuthorship W2257182834A5077558876 @default.
• W2257182834 hasBestOaLocation W22571828341 @default.
• W2257182834 hasConcept C120665830 @default.
• W2257182834 hasConcept C121332964 @default.
• W2257182834 hasConcept C121608353 @default.
• W2257182834 hasConcept C126322002 @default.
• W2257182834 hasConcept C143998085 @default.
• W2257182834 hasConcept C144301174 @default.
• W2257182834 hasConcept C159654299 @default.
• W2257182834 hasConcept C188816634 @default.
• W2257182834 hasConcept C203014093 @default.
• W2257182834 hasConcept C22889606 @default.
• W2257182834 hasConcept C2779134260 @default.
• W2257182834 hasConcept C2781197716 @default.
• W2257182834 hasConcept C32611913 @default.
• W2257182834 hasConcept C38180746 @default.
• W2257182834 hasConcept C55493867 @default.
• W2257182834 hasConcept C61511704 @default.
• W2257182834 hasConcept C71924100 @default.
• W2257182834 hasConcept C86803240 @default.
• W2257182834 hasConcept C90924648 @default.
• W2257182834 hasConceptScore W2257182834C120665830 @default.
• W2257182834 hasConceptScore W2257182834C121332964 @default.
• W2257182834 hasConceptScore W2257182834C121608353 @default.
• W2257182834 hasConceptScore W2257182834C126322002 @default.

• next