Matches in SemOpenAlex for { <https://semopenalex.org/work/W2257264818> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2257264818 endingPage "96" @default.
- W2257264818 startingPage "89" @default.
- W2257264818 abstract "The aim of this study was to provide a clearer definition of the cardiovascular actions of tyramine in intact conscious as well as anesthetized dogs, and where possible to localize the major cardiovascular sites of action. In pentobarbitalized open-chest dogs, pressor doses of tyramine HCl i.v. increased heart rate, cardiac output and force of myocardial contraction. Total peripheral resistance first increased, but then decreased despite the persistence of a pressor response. In unanesthetized trained dogs, using the rate of rise (first derivative) of left ventricular pressure as an index of myocardial contractile response, the responses to tyramine were similar except that heart rate decreased. In addition, the pattern of response with respect to cardiac output and total peripheral resistance was not the same in all animals. During the latter part of the pnesson response, cardiac output was the major determinate of pressure in the majority of animals. Local vasoconstrictor and positive inotropic cardiac effects of tyramine were demonstrated by regional i.a. injections of subpressor doses in anesthetized dogs: pressure/flow ratios increased in renal, mesentenic and femoral vascular beds when minimal doses were injected, respectively, into the renal, superior mesenteric and femoral artery; the force of left ventricular contraction increased when minimal doses were injected into the circumflex branch of the left coronary artery. The hypothesis that tyramine acts indirectly via catecholamine release is supported by the findings that local (renal) vasoconstrictor responses, myocardial contractile responses and pressor responses were reduced by reserpine pretreatment. The results in both anesthetized and unanesthetized animals indicate that both cardiac and vasoconstrictor responses to tyramine must be taken into account whenever the pressor effect is used in analyzing the actions of tyramine and the modification of its action by other drugs." @default.
- W2257264818 created "2016-06-24" @default.
- W2257264818 creator A5005913560 @default.
- W2257264818 creator A5025339140 @default.
- W2257264818 creator A5083444694 @default.
- W2257264818 date "1964-04-01" @default.
- W2257264818 modified "2023-09-23" @default.
- W2257264818 title "HEMODYNAMIC EFFECTS OF TYRAMINE." @default.
- W2257264818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14191471" @default.
- W2257264818 hasPublicationYear "1964" @default.
- W2257264818 type Work @default.
- W2257264818 sameAs 2257264818 @default.
- W2257264818 citedByCount "1" @default.
- W2257264818 crossrefType "journal-article" @default.
- W2257264818 hasAuthorship W2257264818A5005913560 @default.
- W2257264818 hasAuthorship W2257264818A5025339140 @default.
- W2257264818 hasAuthorship W2257264818A5083444694 @default.
- W2257264818 hasConcept C126322002 @default.
- W2257264818 hasConcept C134018914 @default.
- W2257264818 hasConcept C139940330 @default.
- W2257264818 hasConcept C155710745 @default.
- W2257264818 hasConcept C163415756 @default.
- W2257264818 hasConcept C164705383 @default.
- W2257264818 hasConcept C178853913 @default.
- W2257264818 hasConcept C2776077682 @default.
- W2257264818 hasConcept C2776452961 @default.
- W2257264818 hasConcept C2777842393 @default.
- W2257264818 hasConcept C2777953023 @default.
- W2257264818 hasConcept C42219234 @default.
- W2257264818 hasConcept C58245268 @default.
- W2257264818 hasConcept C71924100 @default.
- W2257264818 hasConcept C84393581 @default.
- W2257264818 hasConceptScore W2257264818C126322002 @default.
- W2257264818 hasConceptScore W2257264818C134018914 @default.
- W2257264818 hasConceptScore W2257264818C139940330 @default.
- W2257264818 hasConceptScore W2257264818C155710745 @default.
- W2257264818 hasConceptScore W2257264818C163415756 @default.
- W2257264818 hasConceptScore W2257264818C164705383 @default.
- W2257264818 hasConceptScore W2257264818C178853913 @default.
- W2257264818 hasConceptScore W2257264818C2776077682 @default.
- W2257264818 hasConceptScore W2257264818C2776452961 @default.
- W2257264818 hasConceptScore W2257264818C2777842393 @default.
- W2257264818 hasConceptScore W2257264818C2777953023 @default.
- W2257264818 hasConceptScore W2257264818C42219234 @default.
- W2257264818 hasConceptScore W2257264818C58245268 @default.
- W2257264818 hasConceptScore W2257264818C71924100 @default.
- W2257264818 hasConceptScore W2257264818C84393581 @default.
- W2257264818 hasLocation W22572648181 @default.
- W2257264818 hasOpenAccess W2257264818 @default.
- W2257264818 hasPrimaryLocation W22572648181 @default.
- W2257264818 hasRelatedWork W1980863774 @default.
- W2257264818 hasRelatedWork W1981676652 @default.
- W2257264818 hasRelatedWork W1990331272 @default.
- W2257264818 hasRelatedWork W1991168690 @default.
- W2257264818 hasRelatedWork W1999958402 @default.
- W2257264818 hasRelatedWork W2004218452 @default.
- W2257264818 hasRelatedWork W2033403544 @default.
- W2257264818 hasRelatedWork W2037320249 @default.
- W2257264818 hasRelatedWork W2066408697 @default.
- W2257264818 hasRelatedWork W2088071025 @default.
- W2257264818 hasRelatedWork W2097811889 @default.
- W2257264818 hasRelatedWork W2101057485 @default.
- W2257264818 hasRelatedWork W2107027670 @default.
- W2257264818 hasRelatedWork W2107828529 @default.
- W2257264818 hasRelatedWork W2157929059 @default.
- W2257264818 hasRelatedWork W2255260794 @default.
- W2257264818 hasRelatedWork W2289658013 @default.
- W2257264818 hasRelatedWork W2338883259 @default.
- W2257264818 hasRelatedWork W2409618044 @default.
- W2257264818 hasRelatedWork W2417898938 @default.
- W2257264818 hasVolume "144" @default.
- W2257264818 isParatext "false" @default.
- W2257264818 isRetracted "false" @default.
- W2257264818 magId "2257264818" @default.
- W2257264818 workType "article" @default.