FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2257329287> ?p ?o ?g. }

• W2257329287 endingPage "6082" @default.
• W2257329287 startingPage "6082" @default.
• W2257329287 abstract "6082 Background: During tumor growth, tumor adapts the hypoxic environment and increases glycolysis. This metabolic switch is related to the aggressive malignant behavior. We investigated the connection between the biomarkers related to the glycolytic metabolism (HIF-1α, PDK-1, LDH-5) and clinicopathologic characteristics in oral cavity and oropharynx squamous cell carcinoma (SCC). Methods: Eligibility criteria was the patients diagnosed oral SCC, received curative radical resection and had available tissue samples. Immunohistochemical stain of the HIF-1α, PDK-1, and LDH-5 was done. Statistical analysis was performed to compare biomarkers between patients and time point. Results: Overall 74 patients were enrolled and stage grouping of the patients was as follows: stage I, 25 (33.8%) patients; stage II 17 (23.0%); stage III 8 (10.8%); stage IV 24 (32.4%). 25 patients were relapsed and 5-year disease-free survival (DFS) rate was 61.4%. High expression of HIF-1α was related to the advanced T stage (p = 0.029), more invasive tumor (p = 0.003) and tumor recurrence (p = 0.037). High expression of PDK-1 was related to the advanced N stage (p = 0.026) and high expression of LDH-5 was related to the lymphatics invasion (p = 0.028), advanced N stage (p = 0.020) and more invasive tumor (p = 0.015). The high expression of HIF-1α, PDK-1, and LDH-5 showed a significant correlation to each other. 16 (21.6%) patients were highly expressed all three markers. High expression of all three markers correlated with more invasive tumor (p = 0.004) and tumor recurrence (p = 0.017). In survival analysis, high expression of HIF-1α and LDH-5 associated with shorter DFS in log rank test (p = 0.002 and p = 0.016, respectively). High expression of all three markers was also associated with shorter DFS (p = 0.002). In multivariate Cox regression analysis, high expression of all three markers was strong independent prognostic factor for DFS (p = 0.021). Conclusions: The oral SCC which glycolytic metabolism was changed showed a more invasive and aggressive phenotype. Taken together, biomarkers related tumor metabolism may be independent prognostic markers for the DFS in the patients with oral SCC. No significant financial relationships to disclose." @default.
• W2257329287 created "2016-06-24" @default.
• W2257329287 creator A5014474281 @default.
• W2257329287 creator A5057152891 @default.
• W2257329287 creator A5062577994 @default.
• W2257329287 creator A5064347956 @default.
• W2257329287 creator A5064975394 @default.
• W2257329287 creator A5066586019 @default.
• W2257329287 creator A5067439762 @default.
• W2257329287 creator A5079682715 @default.
• W2257329287 creator A5082511680 @default.
• W2257329287 creator A5088316493 @default.
• W2257329287 date "2009-05-20" @default.
• W2257329287 modified "2023-10-18" @default.
• W2257329287 title "Prognostic significance of metabolic adaptation for hypoxic environment in oral squamous cell carcinoma" @default.
• W2257329287 doi "https://doi.org/10.1200/jco.2009.27.15_suppl.6082" @default.
• W2257329287 hasPublicationYear "2009" @default.
• W2257329287 type Work @default.
• W2257329287 sameAs 2257329287 @default.
• W2257329287 citedByCount "0" @default.
• W2257329287 crossrefType "journal-article" @default.
• W2257329287 hasAuthorship W2257329287A5014474281 @default.
• W2257329287 hasAuthorship W2257329287A5057152891 @default.
• W2257329287 hasAuthorship W2257329287A5062577994 @default.
• W2257329287 hasAuthorship W2257329287A5064347956 @default.
• W2257329287 hasAuthorship W2257329287A5064975394 @default.
• W2257329287 hasAuthorship W2257329287A5066586019 @default.
• W2257329287 hasAuthorship W2257329287A5067439762 @default.
• W2257329287 hasAuthorship W2257329287A5079682715 @default.
• W2257329287 hasAuthorship W2257329287A5082511680 @default.
• W2257329287 hasAuthorship W2257329287A5088316493 @default.
• W2257329287 hasConcept C126322002 @default.
• W2257329287 hasConcept C142724271 @default.
• W2257329287 hasConcept C143998085 @default.
• W2257329287 hasConcept C146357865 @default.
• W2257329287 hasConcept C151730666 @default.
• W2257329287 hasConcept C20251656 @default.
• W2257329287 hasConcept C204232928 @default.
• W2257329287 hasConcept C3018542373 @default.
• W2257329287 hasConcept C3019992690 @default.
• W2257329287 hasConcept C62231903 @default.
• W2257329287 hasConcept C71924100 @default.
• W2257329287 hasConcept C86803240 @default.
• W2257329287 hasConcept C90924648 @default.
• W2257329287 hasConceptScore W2257329287C126322002 @default.
• W2257329287 hasConceptScore W2257329287C142724271 @default.
• W2257329287 hasConceptScore W2257329287C143998085 @default.
• W2257329287 hasConceptScore W2257329287C146357865 @default.
• W2257329287 hasConceptScore W2257329287C151730666 @default.
• W2257329287 hasConceptScore W2257329287C20251656 @default.
• W2257329287 hasConceptScore W2257329287C204232928 @default.
• W2257329287 hasConceptScore W2257329287C3018542373 @default.
• W2257329287 hasConceptScore W2257329287C3019992690 @default.
• W2257329287 hasConceptScore W2257329287C62231903 @default.
• W2257329287 hasConceptScore W2257329287C71924100 @default.
• W2257329287 hasConceptScore W2257329287C86803240 @default.
• W2257329287 hasConceptScore W2257329287C90924648 @default.
• W2257329287 hasIssue "15_suppl" @default.
• W2257329287 hasLocation W22573292871 @default.
• W2257329287 hasOpenAccess W2257329287 @default.
• W2257329287 hasPrimaryLocation W22573292871 @default.
• W2257329287 hasRelatedWork W1981434988 @default.
• W2257329287 hasRelatedWork W1982299814 @default.
• W2257329287 hasRelatedWork W2257329287 @default.
• W2257329287 hasRelatedWork W2356105190 @default.
• W2257329287 hasRelatedWork W2382738577 @default.
• W2257329287 hasRelatedWork W2392074089 @default.
• W2257329287 hasRelatedWork W2616033432 @default.
• W2257329287 hasRelatedWork W2728479721 @default.
• W2257329287 hasRelatedWork W2994700791 @default.
• W2257329287 hasRelatedWork W3120903604 @default.
• W2257329287 hasVolume "27" @default.
• W2257329287 isParatext "false" @default.
• W2257329287 isRetracted "false" @default.
• W2257329287 magId "2257329287" @default.
• W2257329287 workType "article" @default.