FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2257397125> ?p ?o ?g. }

• W2257397125 endingPage "604" @default.
• W2257397125 startingPage "595" @default.
• W2257397125 abstract "The ubiquitous AAA-ATPase p97 segregates ubiquitylated proteins from their molecular environment. Previous studies of the nucleotide-dependent conformational changes of p97 were inconclusive. Here, we determined its structure in the presence of ADP, AMP-PNP, or ATP-γS at 6.1-7.4 Å resolution using single particle cryo-electron microscopy. Both AAA domains, D1 and D2, assemble into essentially six-fold symmetrical rings. The pore of the D1-ring remains essentially closed under all nucleotide conditions, whereas the D2-ring shows an iris-like opening for ADP. The largest conformational changes of p97 are 'swinging motions' of the N-terminal domains, which may enable segregation of ubiquitylated substrates from their environment." @default.
• W2257397125 created "2016-06-24" @default.
• W2257397125 creator A5014597115 @default.
• W2257397125 creator A5053603496 @default.
• W2257397125 creator A5073848521 @default.
• W2257397125 creator A5081245410 @default.
• W2257397125 creator A5091877088 @default.
• W2257397125 date "2016-02-20" @default.
• W2257397125 modified "2023-10-18" @default.
• W2257397125 title "Nucleotide-dependent conformational changes of the AAA+ ATPase p97 revisited" @default.
• W2257397125 cites W1983350301 @default.
• W2257397125 cites W1992875450 @default.
• W2257397125 cites W1994561883 @default.
• W2257397125 cites W1996109826 @default.
• W2257397125 cites W2003079343 @default.
• W2257397125 cites W2011790784 @default.
• W2257397125 cites W2014697177 @default.
• W2257397125 cites W2018753611 @default.
• W2257397125 cites W2025960774 @default.
• W2257397125 cites W2034484189 @default.
• W2257397125 cites W2045102499 @default.
• W2257397125 cites W2048240388 @default.
• W2257397125 cites W2056607803 @default.
• W2257397125 cites W2064140868 @default.
• W2257397125 cites W2069604928 @default.
• W2257397125 cites W2071746920 @default.
• W2257397125 cites W2073949924 @default.
• W2257397125 cites W2076249680 @default.
• W2257397125 cites W2077276173 @default.
• W2257397125 cites W2078813054 @default.
• W2257397125 cites W2080606243 @default.
• W2257397125 cites W2092695683 @default.
• W2257397125 cites W2093338032 @default.
• W2257397125 cites W2099327491 @default.
• W2257397125 cites W2102706169 @default.
• W2257397125 cites W2111455978 @default.
• W2257397125 cites W2111527039 @default.
• W2257397125 cites W2118755520 @default.
• W2257397125 cites W2124892621 @default.
• W2257397125 cites W2141284487 @default.
• W2257397125 cites W2147620484 @default.
• W2257397125 cites W2149360962 @default.
• W2257397125 cites W2151819406 @default.
• W2257397125 cites W2153811192 @default.
• W2257397125 cites W2156577106 @default.
• W2257397125 cites W2160559764 @default.
• W2257397125 cites W2216848450 @default.
• W2257397125 doi "https://doi.org/10.1002/1873-3468.12091" @default.
• W2257397125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26849035" @default.
• W2257397125 hasPublicationYear "2016" @default.
• W2257397125 type Work @default.
• W2257397125 sameAs 2257397125 @default.
• W2257397125 citedByCount "34" @default.
• W2257397125 countsByYear W22573971252016 @default.
• W2257397125 countsByYear W22573971252017 @default.
• W2257397125 countsByYear W22573971252018 @default.
• W2257397125 countsByYear W22573971252019 @default.
• W2257397125 countsByYear W22573971252020 @default.
• W2257397125 countsByYear W22573971252021 @default.
• W2257397125 countsByYear W22573971252023 @default.
• W2257397125 crossrefType "journal-article" @default.
• W2257397125 hasAuthorship W2257397125A5014597115 @default.
• W2257397125 hasAuthorship W2257397125A5053603496 @default.
• W2257397125 hasAuthorship W2257397125A5073848521 @default.
• W2257397125 hasAuthorship W2257397125A5081245410 @default.
• W2257397125 hasAuthorship W2257397125A5091877088 @default.
• W2257397125 hasBestOaLocation W22573971251 @default.
• W2257397125 hasConcept C101635128 @default.
• W2257397125 hasConcept C104317684 @default.
• W2257397125 hasConcept C12554922 @default.
• W2257397125 hasConcept C181199279 @default.
• W2257397125 hasConcept C185592680 @default.
• W2257397125 hasConcept C20702342 @default.
• W2257397125 hasConcept C23265538 @default.
• W2257397125 hasConcept C2777339483 @default.
• W2257397125 hasConcept C47701112 @default.
• W2257397125 hasConcept C512185932 @default.
• W2257397125 hasConcept C55493867 @default.
• W2257397125 hasConcept C71240020 @default.
• W2257397125 hasConcept C8010536 @default.
• W2257397125 hasConcept C86803240 @default.
• W2257397125 hasConceptScore W2257397125C101635128 @default.
• W2257397125 hasConceptScore W2257397125C104317684 @default.
• W2257397125 hasConceptScore W2257397125C12554922 @default.
• W2257397125 hasConceptScore W2257397125C181199279 @default.
• W2257397125 hasConceptScore W2257397125C185592680 @default.
• W2257397125 hasConceptScore W2257397125C20702342 @default.
• W2257397125 hasConceptScore W2257397125C23265538 @default.
• W2257397125 hasConceptScore W2257397125C2777339483 @default.
• W2257397125 hasConceptScore W2257397125C47701112 @default.
• W2257397125 hasConceptScore W2257397125C512185932 @default.
• W2257397125 hasConceptScore W2257397125C55493867 @default.
• W2257397125 hasConceptScore W2257397125C71240020 @default.
• W2257397125 hasConceptScore W2257397125C8010536 @default.
• W2257397125 hasConceptScore W2257397125C86803240 @default.
• W2257397125 hasFunder F4320321800 @default.
• W2257397125 hasIssue "5" @default.
• W2257397125 hasLocation W22573971251 @default.

• next