FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W225748884> ?p ?o ?g. }

• W225748884 endingPage "e0126560" @default.
• W225748884 startingPage "e0126560" @default.
• W225748884 abstract "Enteric fever is a major cause of morbidity in several parts of the Indian subcontinent. The treatment for typhoid fever majorly includes the fluoroquinolone group of antibiotics. Excessive and indiscriminate use of these antibiotics has led to development of acquired resistance in the causative organism Salmonella Typhi. The resistance towards fluoroquinolones is associated with mutations in the target gene of DNA Gyrase. We have estimated the Minimum Inhibitory Concentration (MIC) of commonly used fluoroquinolone representatives from three generations, ciprofloxacin, ofloxacin, levofloxacin and moxifloxacin, for 100 clinical isolates of Salmonella Typhi from patients in the Indian subcontinent. The MICs have been found to be in the range of 0.032 to 8 μg/ml. The gene encoding DNA Gyrase was subsequently sequenced and point mutations were observed in DNA Gyrase in the quinolone resistance determining region comprising Ser83Phe/Tyr and Asp87Tyr/Gly. The binding ability of these four fluoroquinolones in the quinolone binding pocket of wild type as well as mutant DNA Gyrase was computationally analyzed by molecular docking to assess their differential binding behaviour. This study has revealed that mutations in DNA Gyrase alter the characteristics of the binding pocket resulting in the loss of crucial molecular interactions and consequently decrease the binding affinity of fluoroquinolones with the target protein. The present study assists in understanding the underlying molecular and structural mechanism for decreased fluoroquinolone susceptibility in clinical isolates as a consequence of mutations in DNA Gyrase." @default.
• W225748884 created "2016-06-24" @default.
• W225748884 creator A5003774336 @default.
• W225748884 creator A5008131520 @default.
• W225748884 creator A5021700639 @default.
• W225748884 creator A5038733610 @default.
• W225748884 creator A5062351807 @default.
• W225748884 creator A5083794797 @default.
• W225748884 date "2015-05-11" @default.
• W225748884 modified "2023-10-14" @default.
• W225748884 title "Structure Based In Silico Analysis of Quinolone Resistance in Clinical Isolates of Salmonella Typhi from India" @default.
• W225748884 cites W1503153235 @default.
• W225748884 cites W1965511397 @default.
• W225748884 cites W1968490772 @default.
• W225748884 cites W1972176917 @default.
• W225748884 cites W1972799157 @default.
• W225748884 cites W1979700870 @default.
• W225748884 cites W1979973356 @default.
• W225748884 cites W1983304433 @default.
• W225748884 cites W1983455834 @default.
• W225748884 cites W1986191025 @default.
• W225748884 cites W1986332448 @default.
• W225748884 cites W1989228404 @default.
• W225748884 cites W1990810367 @default.
• W225748884 cites W1999613945 @default.
• W225748884 cites W2005526848 @default.
• W225748884 cites W2009078553 @default.
• W225748884 cites W2012231377 @default.
• W225748884 cites W2017835622 @default.
• W225748884 cites W2024558829 @default.
• W225748884 cites W2027214692 @default.
• W225748884 cites W2035266068 @default.
• W225748884 cites W2045669197 @default.
• W225748884 cites W2065283382 @default.
• W225748884 cites W2066082047 @default.
• W225748884 cites W2067174909 @default.
• W225748884 cites W2068305149 @default.
• W225748884 cites W2068935267 @default.
• W225748884 cites W2070600380 @default.
• W225748884 cites W2077398390 @default.
• W225748884 cites W2077921564 @default.
• W225748884 cites W2081220000 @default.
• W225748884 cites W2082126007 @default.
• W225748884 cites W2086634221 @default.
• W225748884 cites W2092133590 @default.
• W225748884 cites W2094966898 @default.
• W225748884 cites W2099470368 @default.
• W225748884 cites W2106140689 @default.
• W225748884 cites W2107861076 @default.
• W225748884 cites W2108064520 @default.
• W225748884 cites W2132697669 @default.
• W225748884 cites W2133641393 @default.
• W225748884 cites W2139363194 @default.
• W225748884 cites W2146778078 @default.
• W225748884 cites W2147421370 @default.
• W225748884 cites W2147637661 @default.
• W225748884 cites W2149410208 @default.
• W225748884 cites W2154806021 @default.
• W225748884 cites W2157007438 @default.
• W225748884 cites W2160122845 @default.
• W225748884 cites W2162166182 @default.
• W225748884 cites W2163169974 @default.
• W225748884 cites W2163727429 @default.
• W225748884 cites W2165003744 @default.
• W225748884 cites W2167787735 @default.
• W225748884 cites W2411270449 @default.
• W225748884 cites W3149078497 @default.
• W225748884 cites W4233875887 @default.
• W225748884 cites W4241841228 @default.
• W225748884 doi "https://doi.org/10.1371/journal.pone.0126560" @default.
• W225748884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4427296" @default.
• W225748884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25962113" @default.
• W225748884 hasPublicationYear "2015" @default.
• W225748884 type Work @default.
• W225748884 sameAs 225748884 @default.
• W225748884 citedByCount "26" @default.
• W225748884 countsByYear W2257488842016 @default.
• W225748884 countsByYear W2257488842017 @default.
• W225748884 countsByYear W2257488842018 @default.
• W225748884 countsByYear W2257488842019 @default.
• W225748884 countsByYear W2257488842020 @default.
• W225748884 countsByYear W2257488842021 @default.
• W225748884 countsByYear W2257488842022 @default.
• W225748884 countsByYear W2257488842023 @default.
• W225748884 crossrefType "journal-article" @default.
• W225748884 hasAuthorship W225748884A5003774336 @default.
• W225748884 hasAuthorship W225748884A5008131520 @default.
• W225748884 hasAuthorship W225748884A5021700639 @default.
• W225748884 hasAuthorship W225748884A5038733610 @default.
• W225748884 hasAuthorship W225748884A5062351807 @default.
• W225748884 hasAuthorship W225748884A5083794797 @default.
• W225748884 hasBestOaLocation W2257488841 @default.
• W225748884 hasConcept C104317684 @default.
• W225748884 hasConcept C167125095 @default.
• W225748884 hasConcept C2778049240 @default.
• W225748884 hasConcept C2778512257 @default.
• W225748884 hasConcept C2778836808 @default.
• W225748884 hasConcept C2779922871 @default.

• next