Matches in SemOpenAlex for { <https://semopenalex.org/work/W2257489030> ?p ?o ?g. }
- W2257489030 abstract "Testicular Leydig cells contain abundant cytoplasmic lipid droplets (LDs) as a cholesteryl-ester store for releasing cholesterols as the precursor substrate for testosterone biosynthesis. Here, we identified the protein composition of testicular LDs purified from adult mice by using mass spectrometry and immunodetection. Among 337 proteins identified, 144 were previously detected in LD proteomes; 44 were confirmed by microscopy. Testicular LDs contained multiple Rab GTPases, chaperones, and proteins involved in glucuronidation, ubiquination and transport, many known to modulate LD formation and LD-related cellular functions. In particular, testicular LDs contained many members of both the perilipin family and classical lipase/esterase superfamily assembled predominately in adipocyte LDs. Thus, testicular LDs might be regulated similar to adipocyte LDs. Remarkably, testicular LDs contained a large number of classical enzymes for biosynthesis and metabolism of cholesterol and hormonal steroids, so steroidogenic reactions might occur on testicular LDs or the steroidogenic enzymes and products could be transferred through testicular LDs. These characteristics differ from the LDs in most other types of cells, so testicular LDs could be an active organelle functionally involved in steroidogenesis." @default.
- W2257489030 created "2016-06-24" @default.
- W2257489030 creator A5004877322 @default.
- W2257489030 creator A5028016932 @default.
- W2257489030 creator A5034255633 @default.
- W2257489030 creator A5035511411 @default.
- W2257489030 creator A5036806170 @default.
- W2257489030 creator A5041433782 @default.
- W2257489030 creator A5061989741 @default.
- W2257489030 creator A5063859648 @default.
- W2257489030 creator A5091075317 @default.
- W2257489030 date "2015-07-10" @default.
- W2257489030 modified "2023-10-16" @default.
- W2257489030 title "Proteomic analysis of murine testes lipid droplets" @default.
- W2257489030 cites W120466310 @default.
- W2257489030 cites W1503405267 @default.
- W2257489030 cites W1976292735 @default.
- W2257489030 cites W1984063971 @default.
- W2257489030 cites W1984150591 @default.
- W2257489030 cites W1984667462 @default.
- W2257489030 cites W1984944152 @default.
- W2257489030 cites W1990017904 @default.
- W2257489030 cites W1993465904 @default.
- W2257489030 cites W1993869709 @default.
- W2257489030 cites W1997238838 @default.
- W2257489030 cites W1997851425 @default.
- W2257489030 cites W2001550114 @default.
- W2257489030 cites W2001601666 @default.
- W2257489030 cites W2002232196 @default.
- W2257489030 cites W2003180539 @default.
- W2257489030 cites W2004462369 @default.
- W2257489030 cites W2010130739 @default.
- W2257489030 cites W2012639119 @default.
- W2257489030 cites W2019981157 @default.
- W2257489030 cites W2023430066 @default.
- W2257489030 cites W2025913358 @default.
- W2257489030 cites W2028628438 @default.
- W2257489030 cites W2038225007 @default.
- W2257489030 cites W2040468164 @default.
- W2257489030 cites W2041210709 @default.
- W2257489030 cites W2042340758 @default.
- W2257489030 cites W2044073767 @default.
- W2257489030 cites W2046333439 @default.
- W2257489030 cites W2048645048 @default.
- W2257489030 cites W2053150532 @default.
- W2257489030 cites W2057511144 @default.
- W2257489030 cites W2059275312 @default.
- W2257489030 cites W2059393543 @default.
- W2257489030 cites W2061795728 @default.
- W2257489030 cites W2062546298 @default.
- W2257489030 cites W2068188827 @default.
- W2257489030 cites W2070643717 @default.
- W2257489030 cites W2071608742 @default.
- W2257489030 cites W2071659327 @default.
- W2257489030 cites W2074162887 @default.
- W2257489030 cites W2077991483 @default.
- W2257489030 cites W2081595348 @default.
- W2257489030 cites W2086500674 @default.
- W2257489030 cites W2091188300 @default.
- W2257489030 cites W2091754068 @default.
- W2257489030 cites W2095798272 @default.
- W2257489030 cites W2096054485 @default.
- W2257489030 cites W2096153672 @default.
- W2257489030 cites W2096192728 @default.
- W2257489030 cites W2101543956 @default.
- W2257489030 cites W2106690639 @default.
- W2257489030 cites W2110096707 @default.
- W2257489030 cites W2110839026 @default.
- W2257489030 cites W2111662425 @default.
- W2257489030 cites W2115274616 @default.
- W2257489030 cites W2117788306 @default.
- W2257489030 cites W2118013260 @default.
- W2257489030 cites W2119023084 @default.
- W2257489030 cites W2121278592 @default.
- W2257489030 cites W2127026603 @default.
- W2257489030 cites W2127158392 @default.
- W2257489030 cites W2127570240 @default.
- W2257489030 cites W2129946955 @default.
- W2257489030 cites W2132218352 @default.
- W2257489030 cites W2132371754 @default.
- W2257489030 cites W2139399016 @default.
- W2257489030 cites W2147347287 @default.
- W2257489030 cites W2153582662 @default.
- W2257489030 cites W2158316596 @default.
- W2257489030 cites W2166446773 @default.
- W2257489030 cites W2169474590 @default.
- W2257489030 cites W2170651583 @default.
- W2257489030 cites W2413461772 @default.
- W2257489030 cites W4241836970 @default.
- W2257489030 doi "https://doi.org/10.1038/srep12070" @default.
- W2257489030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4498221" @default.
- W2257489030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26159641" @default.
- W2257489030 hasPublicationYear "2015" @default.
- W2257489030 type Work @default.
- W2257489030 sameAs 2257489030 @default.
- W2257489030 citedByCount "41" @default.
- W2257489030 countsByYear W22574890302016 @default.
- W2257489030 countsByYear W22574890302017 @default.
- W2257489030 countsByYear W22574890302018 @default.
- W2257489030 countsByYear W22574890302019 @default.