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- W2257505506 endingPage "72" @default.
- W2257505506 startingPage "451" @default.
- W2257505506 abstract "Type 2 diabetes is a complex and heterogeneous disorder presently affecting more than 100 million people worldwide and causing serious socio-economic problems. Appropriate experimental models are essential tools for understanding the pathogenesis, complications, and genetic or environmental influences that increase the risks of type 2 diabetes and testing of various therapeutic agents. The animal models of type 2 diabetes can be obtained either spontaneously or induced by chemicals or dietary or surgical manipulations and/or by combination thereof. In recent years, large number of new genetically modified animal models including transgenic, generalized knock-out and tissue-specific knockout mice have been engineered for the study of diabetes. This review gives an overview on the animal models of type 2 diabetes with reference to their origin/source, characteristic features, underlying causes/mechanism(s), advantages and disadvantages to the investigators in diabetes research. In addition, it especially describes the appropriate selection and usefulness of different animal models in preclinical testing of various new chemical entities (NCEs) for the treatment of type 2 diabetes." @default.
- W2257505506 created "2016-06-24" @default.
- W2257505506 creator A5019579246 @default.
- W2257505506 creator A5049334420 @default.
- W2257505506 date "2007-03-01" @default.
- W2257505506 modified "2023-10-06" @default.
- W2257505506 title "Animal models in type 2 diabetes research: an overview." @default.
- W2257505506 cites W1499470623 @default.
- W2257505506 cites W1525713084 @default.
- W2257505506 cites W156173105 @default.
- W2257505506 cites W1572048900 @default.
- W2257505506 cites W1573095123 @default.
- W2257505506 cites W186790523 @default.
- W2257505506 cites W1888693590 @default.
- W2257505506 cites W1964971351 @default.
- W2257505506 cites W1965393911 @default.
- W2257505506 cites W1971817110 @default.
- W2257505506 cites W1972231322 @default.
- W2257505506 cites W1974292355 @default.
- W2257505506 cites W1975780823 @default.
- W2257505506 cites W1976696460 @default.
- W2257505506 cites W1982371325 @default.
- W2257505506 cites W1982705585 @default.
- W2257505506 cites W1982946550 @default.
- W2257505506 cites W1983524947 @default.
- W2257505506 cites W1987672280 @default.
- W2257505506 cites W1987733833 @default.
- W2257505506 cites W1991694020 @default.
- W2257505506 cites W1995298066 @default.
- W2257505506 cites W1997040781 @default.
- W2257505506 cites W1998228658 @default.
- W2257505506 cites W1998591396 @default.
- W2257505506 cites W1999206977 @default.
- W2257505506 cites W2005631387 @default.
- W2257505506 cites W2007516267 @default.
- W2257505506 cites W2009452514 @default.
- W2257505506 cites W2011115564 @default.
- W2257505506 cites W2011777452 @default.
- W2257505506 cites W2012168904 @default.
- W2257505506 cites W2012774598 @default.
- W2257505506 cites W2013389100 @default.
- W2257505506 cites W2013830975 @default.
- W2257505506 cites W2014204089 @default.
- W2257505506 cites W2015508853 @default.
- W2257505506 cites W2022343930 @default.
- W2257505506 cites W2023612431 @default.
- W2257505506 cites W2026800046 @default.
- W2257505506 cites W2027161267 @default.
- W2257505506 cites W2028354009 @default.
- W2257505506 cites W2032947833 @default.
- W2257505506 cites W2037512627 @default.
- W2257505506 cites W2038087749 @default.
- W2257505506 cites W2039762060 @default.
- W2257505506 cites W2042667620 @default.
- W2257505506 cites W2048941884 @default.
- W2257505506 cites W2052674758 @default.
- W2257505506 cites W2055476935 @default.
- W2257505506 cites W2058406367 @default.
- W2257505506 cites W2060336186 @default.
- W2257505506 cites W2062410865 @default.
- W2257505506 cites W2065738055 @default.
- W2257505506 cites W2069070138 @default.
- W2257505506 cites W2070290955 @default.
- W2257505506 cites W2072998420 @default.
- W2257505506 cites W2073638865 @default.
- W2257505506 cites W2077816716 @default.
- W2257505506 cites W2081824649 @default.
- W2257505506 cites W2082551675 @default.
- W2257505506 cites W2084464906 @default.
- W2257505506 cites W2089332339 @default.
- W2257505506 cites W2093141196 @default.
- W2257505506 cites W2099183507 @default.
- W2257505506 cites W2106870924 @default.
- W2257505506 cites W2107223207 @default.
- W2257505506 cites W2108598204 @default.
- W2257505506 cites W2111253437 @default.
- W2257505506 cites W2111411460 @default.
- W2257505506 cites W2111565802 @default.
- W2257505506 cites W2114215947 @default.
- W2257505506 cites W2117559470 @default.
- W2257505506 cites W2119287538 @default.
- W2257505506 cites W2123508173 @default.
- W2257505506 cites W2124602153 @default.
- W2257505506 cites W2128302780 @default.
- W2257505506 cites W2129733160 @default.
- W2257505506 cites W2138013119 @default.
- W2257505506 cites W2140435484 @default.
- W2257505506 cites W2143345681 @default.
- W2257505506 cites W2143643167 @default.
- W2257505506 cites W2145490597 @default.
- W2257505506 cites W2146034341 @default.
- W2257505506 cites W2148665902 @default.
- W2257505506 cites W2150311613 @default.
- W2257505506 cites W2151355421 @default.
- W2257505506 cites W2153827435 @default.
- W2257505506 cites W2154627665 @default.
- W2257505506 cites W2156604743 @default.
- W2257505506 cites W2157300159 @default.