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- W2257582252 abstract "Brca2 Summary Stable isotope labeling with amino acids in cell culture (SILAC)-based mass spectrometry is a mature technique in semi-quantitative proteomics. In a typical SILAC proteome experiment, tens of thousands of peptides and thousands of (non-redundant) proteins are reliably identified and quantified using e.g., the widely-used MaxQuant software. Further downstream analyses of the result files are then facilitated using (dedicated) spreadsheet-based tools such as MS Excel or Perseus. Although these tools are useful they do not provide full control over the data as compared to a database management or information retrieval system. Moreover, they are prone to data-manipulation errors, lack interoperability and scalability. To remedy this, we have developed a web-based tool called PIQMIe (Proteomics Identifications Quantitations data Management and Integration service), and deployed it on a Cloud computing infrastructure. Here we used PIQMIe to mine and visualize the results from mass spectrometry experiments that not only reveal new DNA repair relevant interactors of the BRCA2 protein but also reveal changes in the BRCA2 complex induced by anti-cancer therapy." @default.
- W2257582252 created "2016-06-24" @default.
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- W2257582252 date "2015-08-19" @default.
- W2257582252 modified "2023-10-08" @default.
- W2257582252 title "PIQMIe: a web tool for semi-quantitative proteomics applied to dissect the mechanism of cancer therapy based on interference with DNA repair." @default.
- W2257582252 doi "https://doi.org/10.5281/zenodo.28530" @default.
- W2257582252 hasPublicationYear "2015" @default.
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