FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2257631604> ?p ?o ?g. }

• W2257631604 endingPage "169" @default.
• W2257631604 startingPage "162" @default.
• W2257631604 abstract "Psychiatric disorders are excellent disease models in which gene-environmental interaction play a significant role in the pathogenesis. Childhood trauma has been known as a significant environmental factor in the progress of, and prognosis for psychiatric illness. Patients with refractory illness usually have more severe symptoms, greater disability, lower quality of life and are at greater risk of suicide than other psychiatric patients. Our literature review uncovered some important clinical factors which modulate response to treatment in psychiatric patients who have experienced childhood trauma. Childhood trauma seems to be a critical determinant of treatment refractoriness in psychotic disorder, bipolar disorder, major depressive disorder, and post-traumatic stress disorder. In patients with psychotic disorders, the relationship between childhood trauma and treatment-refractoriness appears to be mediated by cognitive impairment. In the case of bipolar disorder, the relationship appears to be mediated by greater affective disturbance and earlier onset, while in major depressive disorder the mediating factors are persistent, severe symptoms and frequent recurrence. In suicidal individuals, childhood maltreatment was associated with violent suicidal attempts. In the case of PTSD patients, it appears that childhood trauma makes the brain more vulnerable to subsequent trauma, thus resulting in more severe, refractory symptoms. Given that several studies have suggested that there are distinct subtypes of genetic vulnerability to childhood trauma, it is important to understand how gene-environment interactions influence the course of psychiatric illnesses in order to improve therapeutic strategies." @default.
• W2257631604 created "2016-06-24" @default.
• W2257631604 creator A5059660252 @default.
• W2257631604 creator A5063171777 @default.
• W2257631604 date "2016-10-01" @default.
• W2257631604 modified "2023-10-06" @default.
• W2257631604 title "Influence of interactions between genes and childhood trauma on refractoriness in psychiatric disorders" @default.
• W2257631604 cites W1496088120 @default.
• W2257631604 cites W1567513721 @default.
• W2257631604 cites W1577078797 @default.
• W2257631604 cites W1705752366 @default.
• W2257631604 cites W1823202155 @default.
• W2257631604 cites W1883758818 @default.
• W2257631604 cites W1966011502 @default.
• W2257631604 cites W1966411707 @default.
• W2257631604 cites W1967100996 @default.
• W2257631604 cites W1967602157 @default.
• W2257631604 cites W1971816469 @default.
• W2257631604 cites W1972622971 @default.
• W2257631604 cites W1977874045 @default.
• W2257631604 cites W1978571403 @default.
• W2257631604 cites W1982540819 @default.
• W2257631604 cites W1985992192 @default.
• W2257631604 cites W1986344781 @default.
• W2257631604 cites W1987683287 @default.
• W2257631604 cites W1988631025 @default.
• W2257631604 cites W1991604982 @default.
• W2257631604 cites W1994950269 @default.
• W2257631604 cites W1995833874 @default.
• W2257631604 cites W1999833210 @default.
• W2257631604 cites W2000151841 @default.
• W2257631604 cites W2002652713 @default.
• W2257631604 cites W2006581744 @default.
• W2257631604 cites W2007210861 @default.
• W2257631604 cites W2007862317 @default.
• W2257631604 cites W2008113854 @default.
• W2257631604 cites W2009032524 @default.
• W2257631604 cites W2013581040 @default.
• W2257631604 cites W2013996801 @default.
• W2257631604 cites W2015312511 @default.
• W2257631604 cites W2017690535 @default.
• W2257631604 cites W2018630482 @default.
• W2257631604 cites W2019763316 @default.
• W2257631604 cites W2020386120 @default.
• W2257631604 cites W2025509393 @default.
• W2257631604 cites W2028429122 @default.
• W2257631604 cites W2029267876 @default.
• W2257631604 cites W2035309865 @default.
• W2257631604 cites W2040259741 @default.
• W2257631604 cites W2040546819 @default.
• W2257631604 cites W2040973635 @default.
• W2257631604 cites W2043410078 @default.
• W2257631604 cites W2046405426 @default.
• W2257631604 cites W2046650821 @default.
• W2257631604 cites W2046896809 @default.
• W2257631604 cites W2048986230 @default.
• W2257631604 cites W2049695419 @default.
• W2257631604 cites W2050822559 @default.
• W2257631604 cites W2050938807 @default.
• W2257631604 cites W2051772523 @default.
• W2257631604 cites W2055470737 @default.
• W2257631604 cites W2057881388 @default.
• W2257631604 cites W2058147190 @default.
• W2257631604 cites W2062682953 @default.
• W2257631604 cites W2065297016 @default.
• W2257631604 cites W2068480672 @default.
• W2257631604 cites W2069215381 @default.
• W2257631604 cites W2073579715 @default.
• W2257631604 cites W2073983299 @default.
• W2257631604 cites W2085926540 @default.
• W2257631604 cites W2086982565 @default.
• W2257631604 cites W2087074401 @default.
• W2257631604 cites W2087252276 @default.
• W2257631604 cites W2087414280 @default.
• W2257631604 cites W2091023864 @default.
• W2257631604 cites W2094034756 @default.
• W2257631604 cites W2094558352 @default.
• W2257631604 cites W2097940171 @default.
• W2257631604 cites W2100230238 @default.
• W2257631604 cites W2101782343 @default.
• W2257631604 cites W2105167570 @default.
• W2257631604 cites W2114879270 @default.
• W2257631604 cites W2115221577 @default.
• W2257631604 cites W2116839388 @default.
• W2257631604 cites W2117734944 @default.
• W2257631604 cites W2118993750 @default.
• W2257631604 cites W2119389629 @default.
• W2257631604 cites W2120222617 @default.
• W2257631604 cites W2120670471 @default.
• W2257631604 cites W2124335115 @default.
• W2257631604 cites W2124948190 @default.
• W2257631604 cites W2127201367 @default.
• W2257631604 cites W2130034650 @default.
• W2257631604 cites W2133088395 @default.
• W2257631604 cites W2143323047 @default.
• W2257631604 cites W2145499550 @default.
• W2257631604 cites W2146796191 @default.
• W2257631604 cites W2147351252 @default.

• next