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- W2257665680 endingPage "238" @default.
- W2257665680 startingPage "223" @default.
- W2257665680 abstract "Relatively little is known about the neuropathophysiology of binge-eating disorder (BED). Here, the evidence from neuroimaging, neurocognitive, genetics, and animal studies are reviewed to synthesize our current understanding of the pathophysiology of BED. Binge-eating disorder may be conceptualized as an impulsive/compulsive disorder, with altered reward sensitivity and food-related attentional biases. Neuroimaging studies suggest there are corticostriatal circuitry alterations in BED similar to those observed in substance abuse, including altered function of prefrontal, insular, and orbitofrontal cortices and the striatum. Human genetics and animal studies suggest that there are changes in neurotransmitter networks, including dopaminergic and opioidergic systems, associated with binge-eating behaviors. Overall, the current evidence suggests that BED may be related to maladaptation of the corticostriatal circuitry regulating motivation and impulse control similar to that found in other impulsive/compulsive disorders. Further studies are needed to understand the genetics of BED and how neurotransmitter activity and neurocircuitry function are altered in BED and how pharmacotherapies may influence these systems to reduce BED symptoms." @default.
- W2257665680 created "2016-06-24" @default.
- W2257665680 creator A5022439742 @default.
- W2257665680 creator A5042105567 @default.
- W2257665680 creator A5067499997 @default.
- W2257665680 creator A5085278505 @default.
- W2257665680 date "2016-04-01" @default.
- W2257665680 modified "2023-10-01" @default.
- W2257665680 title "The neurobiological basis of binge-eating disorder" @default.
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