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- W2257673793 abstract "Invading pathogens elicit potent immune responses in cells through interactions between structurally conserved molecules derived from the pathogens and specialized innate immune receptors such as the Toll-like receptors (TLRs). Nucleic acid is one of the principal TLR ligands. Nucleic acid-sensing TLRs recognize an array of nucleic acids, including double-stranded RNA, single-stranded RNA, and DNAs with specific sequence motifs. Although ligand-induced dimerization is commonly observed followed by TLR activation, both the specific recognition mechanisms and the ligand–receptor interactions vary among different TLRs. In this review, we highlight our current understanding of how these receptors recognize their cognate ligands based on the recent advances in structural biology." @default.
- W2257673793 created "2016-06-24" @default.
- W2257673793 creator A5014507741 @default.
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- W2257673793 date "2016-02-12" @default.
- W2257673793 modified "2023-10-17" @default.
- W2257673793 title "Structural aspects of nucleic acid-sensing Toll-like receptors" @default.
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- W2257673793 doi "https://doi.org/10.1007/s12551-015-0187-1" @default.
- W2257673793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5425962" @default.
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