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• W2257881775 abstract "Abstract Background & Aims Nonsteroidal anti‐inflammatory drugs ( NSAID s) are commonly used and have been associated with hepatotoxicity. Studies of liver injury from NSAID s have been retrospective and prospective data are lacking. The aim was to report the features and outcomes of the subjects with severe drug‐induced liver injury from NSAIDS . Methods The U.S. Drug Induced Liver Injury Network is a prospective registry of idiosyncratic drug hepatotoxicity. All patients are evaluated in a standard fashion and followed up for at least 6 months. Results Of 1221 Drug Induced Liver Injury Network cases that were adjudicated, 30 cases were attributed to eight different NSAID s. The mean age was 52 years old, 24 (80%) were women, and 21 (70%) were Caucasian. The mean latency was 67 days. Common signs and symptoms at presentation were nausea (73%), jaundice (67%) and dark urine (67%). Mean peak serum aspartate aminotransferase, alanine aminotransferase, total bilirubin and alkaline phosphatase were 898 U/L, 1060 U/L, 12.2 mg/dl and 326 U/L. The most common pattern of injury was hepatocellular (70%) and autoantibodies were detected in 33% of cases. Diclofenac, was the most frequently implicated NSAID (16/30 cases), and characterized by hepatocellular injury. Seventeen cases resulted in hospitalization or prolongation of hospitalization and one patient died from complications of Stevens–Johnson syndrome because of diclofenac. Conclusions Hepatocellular injury is the most common pattern seen with NSAID hepatotoxicity, and diclofenac is the most frequently implicated agent. Given the number of NSAID alternatives, diclofenac should be reserved for patients who fail other NSAID s and a high level of suspicion for hepatotoxicity should be maintained." @default.
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• W2257881775 date "2015-12-15" @default.
• W2257881775 modified "2023-10-16" @default.
• W2257881775 title "Liver injury from nonsteroidal anti‐inflammatory drugs in the United States" @default.
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• W2257881775 doi "https://doi.org/10.1111/liv.13032" @default.
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