Matches in SemOpenAlex for { <https://semopenalex.org/work/W2257883259> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2257883259 endingPage "61" @default.
- W2257883259 startingPage "654" @default.
- W2257883259 abstract "The effects of xenin 25, a peptide of the neurotensin/xenopsin family, were examined on the motility of the guinea pig jejunum and colon in vitro. In the jejunum, xenin induced a biphasic response: first a small relaxation and then a large contraction. In the colon, xenin induced relaxation. The tenia coli was contracted. Deletion or amidation of the C-terminal leucine inactivated xenin. A peptide sequence of 16 C-terminal amino acids was necessary to elicit a full response in the jejunum, whereas in the colon, the potencies of all fragments of xenin 25, including the 6 C-terminal amino acid sequence (xenin 6), were not significantly different from that of xenin 25. In the jejunum, contraction was abolished or reduced by tetrodotoxin, by atropine, by met-enkephalin, by antagonists to the tachykinin receptors NK1 and NK2 and by the P2-purinoceptor antagonist suramin. L-NNA, phentolamine, methysergide, hexamethonium and apamin had no effect. In the colon, all actions of xenin were tetrodotoxin-resistant; the potency of xenin to relax was reduced by apamin and suramin. The actions of xenin on small and large bowel were attenuated by the neurotensin receptor antagonist SR 48692. The xenin analog neurotensin was significantly less potent than xenin 25 in contracting the jejunum and more potent than xenin 25 in relaxing the colon. We conclude that xenin exerts excitatory effects on a neuronal subtype receptor in the jejunum, with participation of muscarinic, purinergic and tachykinin-related mechanisms. Xenin exerts relaxing effects on the colon by interaction with a myokinetic subtype receptor involving Ca(++)-dependent K+ channels and the P2-purinoceptor." @default.
- W2257883259 created "2016-06-24" @default.
- W2257883259 creator A5009834560 @default.
- W2257883259 creator A5021774726 @default.
- W2257883259 creator A5027863204 @default.
- W2257883259 creator A5033562972 @default.
- W2257883259 creator A5063258527 @default.
- W2257883259 date "1996-08-01" @default.
- W2257883259 modified "2023-09-23" @default.
- W2257883259 title "Neurokinetic and myokinetic effects of the peptide xenin on the motility of the small and large intestine of guinea pig." @default.
- W2257883259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8768716" @default.
- W2257883259 hasPublicationYear "1996" @default.
- W2257883259 type Work @default.
- W2257883259 sameAs 2257883259 @default.
- W2257883259 citedByCount "4" @default.
- W2257883259 countsByYear W22578832592012 @default.
- W2257883259 countsByYear W22578832592020 @default.
- W2257883259 crossrefType "journal-article" @default.
- W2257883259 hasAuthorship W2257883259A5009834560 @default.
- W2257883259 hasAuthorship W2257883259A5021774726 @default.
- W2257883259 hasAuthorship W2257883259A5027863204 @default.
- W2257883259 hasAuthorship W2257883259A5033562972 @default.
- W2257883259 hasAuthorship W2257883259A5063258527 @default.
- W2257883259 hasConcept C118303440 @default.
- W2257883259 hasConcept C126322002 @default.
- W2257883259 hasConcept C134018914 @default.
- W2257883259 hasConcept C170493617 @default.
- W2257883259 hasConcept C185592680 @default.
- W2257883259 hasConcept C2776182878 @default.
- W2257883259 hasConcept C2776366702 @default.
- W2257883259 hasConcept C2776919887 @default.
- W2257883259 hasConcept C2777593968 @default.
- W2257883259 hasConcept C2778976297 @default.
- W2257883259 hasConcept C71924100 @default.
- W2257883259 hasConcept C83743174 @default.
- W2257883259 hasConcept C86803240 @default.
- W2257883259 hasConcept C98274493 @default.
- W2257883259 hasConceptScore W2257883259C118303440 @default.
- W2257883259 hasConceptScore W2257883259C126322002 @default.
- W2257883259 hasConceptScore W2257883259C134018914 @default.
- W2257883259 hasConceptScore W2257883259C170493617 @default.
- W2257883259 hasConceptScore W2257883259C185592680 @default.
- W2257883259 hasConceptScore W2257883259C2776182878 @default.
- W2257883259 hasConceptScore W2257883259C2776366702 @default.
- W2257883259 hasConceptScore W2257883259C2776919887 @default.
- W2257883259 hasConceptScore W2257883259C2777593968 @default.
- W2257883259 hasConceptScore W2257883259C2778976297 @default.
- W2257883259 hasConceptScore W2257883259C71924100 @default.
- W2257883259 hasConceptScore W2257883259C83743174 @default.
- W2257883259 hasConceptScore W2257883259C86803240 @default.
- W2257883259 hasConceptScore W2257883259C98274493 @default.
- W2257883259 hasIssue "2" @default.
- W2257883259 hasLocation W22578832591 @default.
- W2257883259 hasOpenAccess W2257883259 @default.
- W2257883259 hasPrimaryLocation W22578832591 @default.
- W2257883259 hasRelatedWork W1583656469 @default.
- W2257883259 hasRelatedWork W1979314801 @default.
- W2257883259 hasRelatedWork W2031272904 @default.
- W2257883259 hasRelatedWork W2042235105 @default.
- W2257883259 hasRelatedWork W2060795725 @default.
- W2257883259 hasRelatedWork W2079966625 @default.
- W2257883259 hasRelatedWork W2095374430 @default.
- W2257883259 hasRelatedWork W2257883259 @default.
- W2257883259 hasRelatedWork W2473249024 @default.
- W2257883259 hasRelatedWork W2771716728 @default.
- W2257883259 hasVolume "278" @default.
- W2257883259 isParatext "false" @default.
- W2257883259 isRetracted "false" @default.
- W2257883259 magId "2257883259" @default.
- W2257883259 workType "article" @default.