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- W2257936017 endingPage "3995" @default.
- W2257936017 startingPage "3983" @default.
- W2257936017 abstract "Oligodendrocytes produce myelin, an insulating sheath required for the saltatory conduction of electrical impulses along axons. Oligodendrocyte loss results in demyelination, which leads to impaired neurological function in a broad array of diseases ranging from pediatric leukodystrophies and cerebral palsy, to multiple sclerosis and white matter stroke. Accordingly, replacing lost oligodendrocytes, whether by transplanting oligodendrocyte progenitor cells (OPCs) or by mobilizing endogenous progenitors, holds great promise as a therapeutic strategy for the diseases of central white matter. In this Primer, we describe the molecular events regulating oligodendrocyte development and how our understanding of this process has led to the establishment of methods for producing OPCs and oligodendrocytes from embryonic stem cells and induced pluripotent stem cells, as well as directly from somatic cells. In addition, we will discuss the safety of engrafted stem cell-derived OPCs, as well as approaches by which to modulate their differentiation and myelinogenesis in vivo following transplantation." @default.
- W2257936017 created "2016-06-24" @default.
- W2257936017 creator A5030957757 @default.
- W2257936017 creator A5032584291 @default.
- W2257936017 date "2015-12-01" @default.
- W2257936017 modified "2023-10-15" @default.
- W2257936017 title "How to make an oligodendrocyte" @default.
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