Matches in SemOpenAlex for { <https://semopenalex.org/work/W2258055262> ?p ?o ?g. }
- W2258055262 endingPage "2438" @default.
- W2258055262 startingPage "2431" @default.
- W2258055262 abstract "An array of specific and non‑specific molecules, which are expressed in the testis, have been demonstrated to be responsible for testicular function. Our previous study revealed that dermatopontin (DPT) is expressed in Sertoli cells of the testis, however, its roles in testicular function remains somewhat elusive. In the present study, CdCl2‑ and busulfan‑induced testicular dysfunction models were used to investigate the implications of DPT expression for testicular function. The mRNA and protein expression levels of DPT were detected using reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively. A negative correlation was observed between testicular damage and the expression of DPT, which suggested that an increase in DPT expression may be a marker for testicular dysfunction. This result was corroborated by the finding that transgenic mice exhibiting Sertoli cell‑specific overexpression of DPT exhibited damage to their testicular morphology. Additionally, DPT overexpression in the testis affected the expression levels of claudin‑11 and zonula occludens‑1, which indicated that DPT may affect testicular function by affecting the integrity of the blood‑testis barrier (BTB). In conclusion, the present study provided evidence to suggest that DPT may be indicative of mouse testicular dysfunction, since increased expression may be associated with damage to the BTB." @default.
- W2258055262 created "2016-06-24" @default.
- W2258055262 creator A5006219539 @default.
- W2258055262 creator A5024414302 @default.
- W2258055262 creator A5042198084 @default.
- W2258055262 creator A5072545319 @default.
- W2258055262 creator A5091305811 @default.
- W2258055262 date "2016-02-05" @default.
- W2258055262 modified "2023-10-16" @default.
- W2258055262 title "Increased expression of dermatopontin and its implications for testicular dysfunction in mice" @default.
- W2258055262 cites W1494444796 @default.
- W2258055262 cites W1513780378 @default.
- W2258055262 cites W1679034681 @default.
- W2258055262 cites W1976246504 @default.
- W2258055262 cites W1982929417 @default.
- W2258055262 cites W1984571847 @default.
- W2258055262 cites W2004469122 @default.
- W2258055262 cites W2009416570 @default.
- W2258055262 cites W2010651448 @default.
- W2258055262 cites W2013411735 @default.
- W2258055262 cites W2026486930 @default.
- W2258055262 cites W2026777536 @default.
- W2258055262 cites W2027176864 @default.
- W2258055262 cites W2031853363 @default.
- W2258055262 cites W2033540001 @default.
- W2258055262 cites W2036524805 @default.
- W2258055262 cites W2053432537 @default.
- W2258055262 cites W2056572278 @default.
- W2258055262 cites W2063400088 @default.
- W2258055262 cites W2072661314 @default.
- W2258055262 cites W2083604900 @default.
- W2258055262 cites W2085133395 @default.
- W2258055262 cites W2093187124 @default.
- W2258055262 cites W2096374348 @default.
- W2258055262 cites W2102679079 @default.
- W2258055262 cites W2103732978 @default.
- W2258055262 cites W2129749274 @default.
- W2258055262 cites W2146363028 @default.
- W2258055262 cites W2147589023 @default.
- W2258055262 cites W2149543418 @default.
- W2258055262 cites W2150333796 @default.
- W2258055262 cites W2150655196 @default.
- W2258055262 cites W2155781883 @default.
- W2258055262 cites W2156510888 @default.
- W2258055262 cites W2158690257 @default.
- W2258055262 cites W2171030691 @default.
- W2258055262 doi "https://doi.org/10.3892/mmr.2016.4879" @default.
- W2258055262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4768960" @default.
- W2258055262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26861869" @default.
- W2258055262 hasPublicationYear "2016" @default.
- W2258055262 type Work @default.
- W2258055262 sameAs 2258055262 @default.
- W2258055262 citedByCount "5" @default.
- W2258055262 countsByYear W22580552622017 @default.
- W2258055262 countsByYear W22580552622020 @default.
- W2258055262 countsByYear W22580552622021 @default.
- W2258055262 crossrefType "journal-article" @default.
- W2258055262 hasAuthorship W2258055262A5006219539 @default.
- W2258055262 hasAuthorship W2258055262A5024414302 @default.
- W2258055262 hasAuthorship W2258055262A5042198084 @default.
- W2258055262 hasAuthorship W2258055262A5072545319 @default.
- W2258055262 hasAuthorship W2258055262A5091305811 @default.
- W2258055262 hasBestOaLocation W22580552621 @default.
- W2258055262 hasConcept C102230213 @default.
- W2258055262 hasConcept C104317684 @default.
- W2258055262 hasConcept C123765429 @default.
- W2258055262 hasConcept C126322002 @default.
- W2258055262 hasConcept C134018914 @default.
- W2258055262 hasConcept C16685009 @default.
- W2258055262 hasConcept C190283241 @default.
- W2258055262 hasConcept C2779066085 @default.
- W2258055262 hasConcept C2781018059 @default.
- W2258055262 hasConcept C2781068068 @default.
- W2258055262 hasConcept C29537977 @default.
- W2258055262 hasConcept C54355233 @default.
- W2258055262 hasConcept C67082663 @default.
- W2258055262 hasConcept C71924100 @default.
- W2258055262 hasConcept C84298646 @default.
- W2258055262 hasConcept C85265743 @default.
- W2258055262 hasConcept C86803240 @default.
- W2258055262 hasConcept C97037327 @default.
- W2258055262 hasConceptScore W2258055262C102230213 @default.
- W2258055262 hasConceptScore W2258055262C104317684 @default.
- W2258055262 hasConceptScore W2258055262C123765429 @default.
- W2258055262 hasConceptScore W2258055262C126322002 @default.
- W2258055262 hasConceptScore W2258055262C134018914 @default.
- W2258055262 hasConceptScore W2258055262C16685009 @default.
- W2258055262 hasConceptScore W2258055262C190283241 @default.
- W2258055262 hasConceptScore W2258055262C2779066085 @default.
- W2258055262 hasConceptScore W2258055262C2781018059 @default.
- W2258055262 hasConceptScore W2258055262C2781068068 @default.
- W2258055262 hasConceptScore W2258055262C29537977 @default.
- W2258055262 hasConceptScore W2258055262C54355233 @default.
- W2258055262 hasConceptScore W2258055262C67082663 @default.
- W2258055262 hasConceptScore W2258055262C71924100 @default.
- W2258055262 hasConceptScore W2258055262C84298646 @default.
- W2258055262 hasConceptScore W2258055262C85265743 @default.
- W2258055262 hasConceptScore W2258055262C86803240 @default.