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- W2258061729 abstract "Desertomycin A is an aminopolyol polyketide containing a macrolactone ring. We have proposed that desertomycin A and similar compounds (marginolactones) are formed by polyketide synthases primed not with γ-aminobutanoyl-CoA but with 4-guanidinylbutanoyl-CoA, to avoid facile cyclization of the starter unit. This hypothesis requires that there be a final-stage de-amidination of the corresponding guanidino-substituted natural product, but no enzyme for such a process has been described. We have now identified candidate amidinohydrolase genes within the desertomycin and primycin clusters. Deletion of the putative desertomycin amidinohydrolase gene dstH in Streptomyces macronensis led to the accumulation of desertomycin B, the guanidino form of the antibiotic. Also, purified DstH efficiently catalyzed the in vitro conversion of desertomycin B into the A form. Hence this amidinohydrolase furnishes the missing link in this proposed naturally evolved example of protective-group chemistry." @default.
- W2258061729 created "2016-06-24" @default.
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- W2258061729 date "2015-12-02" @default.
- W2258061729 modified "2023-10-16" @default.
- W2258061729 title "An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone Antibiotics" @default.
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- W2258061729 cites W1514260722 @default.
- W2258061729 cites W1539666465 @default.
- W2258061729 cites W1584830902 @default.
- W2258061729 cites W1896660825 @default.
- W2258061729 cites W1964895549 @default.
- W2258061729 cites W1965315943 @default.
- W2258061729 cites W1965404937 @default.
- W2258061729 cites W1966203046 @default.
- W2258061729 cites W1969153582 @default.
- W2258061729 cites W1970413517 @default.
- W2258061729 cites W1970954035 @default.
- W2258061729 cites W1971931320 @default.
- W2258061729 cites W1972471493 @default.
- W2258061729 cites W1978336624 @default.
- W2258061729 cites W1980498900 @default.
- W2258061729 cites W1981289547 @default.
- W2258061729 cites W1982101649 @default.
- W2258061729 cites W1982793579 @default.
- W2258061729 cites W1994311423 @default.
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- W2258061729 cites W1996610802 @default.
- W2258061729 cites W1999686598 @default.
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- W2258061729 cites W2018210843 @default.
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- W2258061729 cites W2023376243 @default.
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- W2258061729 doi "https://doi.org/10.1002/anie.201509300" @default.
- W2258061729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4737276" @default.
- W2258061729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26630438" @default.
- W2258061729 hasPublicationYear "2015" @default.
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