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- W2258088045 abstract "4069 Background: The incidence of hepatocellular carcinoma (HCC) is increasing because of the dissemination of hepatitis C virus (HCV) infection worldwide. Therefore, an appropriate method to predict HCV-related HCC is needed. Methods: To investigate an association between the mutation in the PKR-binding domain (PKR-bd: NS5A 2209–2274) of the HCV-NS5A protein and the incidence of HCC, sequential data of HCV-1b genomic regions were obtained from available published data (n=82) by the MEDLINE data base and our clinical data (n=125), in which the regions were amplified and directly sequenced from serum samples obtained from 207 patients with chronic liver diseases [HCV-1b infection or HCV-1b-related cirrhosis], 80 with and 127 without HCC. None of them had received interferon therapies. The PKR-bd mutant was defined to have more than 4 amino acid substitutions, the PKR-bd intermediate had 1 to 3 amino acid substitutions, and the PKR-bd wild had no amino acid substitutions. We compared categorical data by the chi-square test. P < 0.05 was considered significant. Results: The incidence of HCV-1b-related HCC in the PKR-bd wild, the PKR-bd intermediate and the PKR-bd mutant was 6/26 (23.1 %), 39/119 (32.8 %) and 35/62 (56.5 %), respectively. Therefore, the incidence of HCV-1b-related HCC was significantly higher in the PKR-bd mutant than the others (mutant vs wild, p=0.004: mutant vs intermediate, p=0.002). Especially, the relative risk for HCV-1b-related HCC in the PKR-bd mutant was 2.45 (95 % CI: 1.17–5.10) compared to the PKR-bd wild. Conclusions: The risk of HCV-1b-related HCC can be predicted by the mutation in the PKR-bd. And, the PKR-bd mutant is super high risk group of HCV-1b-related HCC. No significant financial relationships to disclose." @default.
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- W2258088045 date "2004-07-15" @default.
- W2258088045 modified "2023-10-18" @default.
- W2258088045 title "A predictive method for HCV-related hepatocellular carcinoma by using clinical genomics: meta-analysis of individual patient data" @default.
- W2258088045 doi "https://doi.org/10.1200/jco.2004.22.90140.4069" @default.
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