FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2258216668> ?p ?o ?g. }

• W2258216668 endingPage "1247" @default.
• W2258216668 startingPage "1237" @default.
• W2258216668 abstract "ABSTRACT The NF-κB family plays key roles in immune and stress responses, and its deregulation contributes to several diseases. Therefore its modulation has become an important therapeutic target. Here, we used a high-throughput screen for small molecules that directly inhibit dimerization of the NF-κB protein p65. One of the identified inhibitors is withaferin A (WFA), a documented anticancer and anti-inflammatory compound. Computational modeling suggests that WFA contacts the dimerization interface on one subunit and surface residues E285 and Q287 on the other. Despite their locations far from the dimerization site, E285 and Q287 substitutions diminished both dimerization and the WFA effect. Further investigation revealed that their effects on dimerization are associated with their proximity to a conserved hydrophobic core domain (HCD) that is crucial for dimerization and DNA binding. Our findings established NF-κB dimerization as a drug target and uncovered an allosteric domain as a target of WFA action." @default.
• W2258216668 created "2016-06-24" @default.
• W2258216668 creator A5009140190 @default.
• W2258216668 creator A5013880187 @default.
• W2258216668 creator A5036544988 @default.
• W2258216668 creator A5044725443 @default.
• W2258216668 creator A5077424058 @default.
• W2258216668 creator A5081842978 @default.
• W2258216668 date "2016-04-15" @default.
• W2258216668 modified "2023-10-12" @default.
• W2258216668 title "A Novel Allosteric Mechanism of NF-κB Dimerization and DNA Binding Targeted by an Anti-Inflammatory Drug" @default.
• W2258216668 cites W151015516 @default.
• W2258216668 cites W1533021978 @default.
• W2258216668 cites W1964920791 @default.
• W2258216668 cites W1975598191 @default.
• W2258216668 cites W1975691556 @default.
• W2258216668 cites W1991483463 @default.
• W2258216668 cites W2004583149 @default.
• W2258216668 cites W2009777487 @default.
• W2258216668 cites W2023877008 @default.
• W2258216668 cites W2031168104 @default.
• W2258216668 cites W2036145275 @default.
• W2258216668 cites W2044698222 @default.
• W2258216668 cites W2051537268 @default.
• W2258216668 cites W2059495814 @default.
• W2258216668 cites W2067011369 @default.
• W2258216668 cites W2070624290 @default.
• W2258216668 cites W2071760372 @default.
• W2258216668 cites W2079003739 @default.
• W2258216668 cites W2086353001 @default.
• W2258216668 cites W2086405064 @default.
• W2258216668 cites W2092459489 @default.
• W2258216668 cites W2093481978 @default.
• W2258216668 cites W2102144390 @default.
• W2258216668 cites W2106756035 @default.
• W2258216668 cites W2110440735 @default.
• W2258216668 cites W2114160655 @default.
• W2258216668 cites W2117692326 @default.
• W2258216668 cites W2120647427 @default.
• W2258216668 cites W2121652706 @default.
• W2258216668 cites W2123105952 @default.
• W2258216668 cites W2133693793 @default.
• W2258216668 cites W2133751949 @default.
• W2258216668 cites W2134062610 @default.
• W2258216668 cites W2136478693 @default.
• W2258216668 cites W2140124506 @default.
• W2258216668 cites W2148119611 @default.
• W2258216668 cites W2157973267 @default.
• W2258216668 cites W2228666292 @default.
• W2258216668 cites W2257903857 @default.
• W2258216668 cites W2262425995 @default.
• W2258216668 cites W2470223656 @default.
• W2258216668 doi "https://doi.org/10.1128/mcb.00895-15" @default.
• W2258216668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4836272" @default.
• W2258216668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26830231" @default.
• W2258216668 hasPublicationYear "2016" @default.
• W2258216668 type Work @default.
• W2258216668 sameAs 2258216668 @default.
• W2258216668 citedByCount "19" @default.
• W2258216668 countsByYear W22582166682016 @default.
• W2258216668 countsByYear W22582166682017 @default.
• W2258216668 countsByYear W22582166682018 @default.
• W2258216668 countsByYear W22582166682019 @default.
• W2258216668 countsByYear W22582166682020 @default.
• W2258216668 countsByYear W22582166682021 @default.
• W2258216668 countsByYear W22582166682022 @default.
• W2258216668 countsByYear W22582166682023 @default.
• W2258216668 crossrefType "journal-article" @default.
• W2258216668 hasAuthorship W2258216668A5009140190 @default.
• W2258216668 hasAuthorship W2258216668A5013880187 @default.
• W2258216668 hasAuthorship W2258216668A5036544988 @default.
• W2258216668 hasAuthorship W2258216668A5044725443 @default.
• W2258216668 hasAuthorship W2258216668A5077424058 @default.
• W2258216668 hasAuthorship W2258216668A5081842978 @default.
• W2258216668 hasBestOaLocation W22582166681 @default.
• W2258216668 hasConcept C104292427 @default.
• W2258216668 hasConcept C104317684 @default.
• W2258216668 hasConcept C107824862 @default.
• W2258216668 hasConcept C161624437 @default.
• W2258216668 hasConcept C166342909 @default.
• W2258216668 hasConcept C181199279 @default.
• W2258216668 hasConcept C202751555 @default.
• W2258216668 hasConcept C2776120743 @default.
• W2258216668 hasConcept C2777730290 @default.
• W2258216668 hasConcept C2780035454 @default.
• W2258216668 hasConcept C51639874 @default.
• W2258216668 hasConcept C552990157 @default.
• W2258216668 hasConcept C55493867 @default.
• W2258216668 hasConcept C62478195 @default.
• W2258216668 hasConcept C70721500 @default.
• W2258216668 hasConcept C74187038 @default.
• W2258216668 hasConcept C86803240 @default.
• W2258216668 hasConcept C95444343 @default.
• W2258216668 hasConcept C98274493 @default.
• W2258216668 hasConceptScore W2258216668C104292427 @default.
• W2258216668 hasConceptScore W2258216668C104317684 @default.
• W2258216668 hasConceptScore W2258216668C107824862 @default.
• W2258216668 hasConceptScore W2258216668C161624437 @default.

• next