FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2258250979> ?p ?o ?g. }

• W2258250979 endingPage "10684" @default.
• W2258250979 startingPage "10675" @default.
• W2258250979 abstract "Aberrant methylation of promoter CpG islands is one of the most important inactivation mechanisms for tumor suppressor and tumor-related genes. Previous studies using genome-wide DNA methylation microarray analysis have suggested the existence of a CpG island methylator phenotype (CIMP) in lung adenocarcinomas. Although the biological behavior of these tumors varies according to tumor stage, no large-scale study has examined the CIMP in lung adenocarcinoma patients according to tumor stage. Furthermore, there have been no reported results regarding the clinical significance of each of the six CIMP markers. To examine the CIMP in patients with pulmonary adenocarcinoma after a surgical resection, we performed methylation analysis of six genes (CCNA1, ACAN, GFRA1, EDARADD, MGC45800, and p16 (INK4A)) in 230 pulmonary adenocarcinoma cases using the SEQUENOM MassARRAY platform. Fifty-four patients (28 %, 54/191) were in the CIMP-high (CIMP-H) group associated with high nodal stage (P = 0.007), the presence of micropapillary or solid histology (P = 0.003), and the absence of an epidermal growth factor receptor (EGFR) mutation (P = 0.002). By multivariate analysis, CIMP was an independent prognostic marker for overall survival (OS) and disease-specific survival (P = 0.03 and P = 0.43, respectively). In the stage I subgroups alone, CIMP-H patients had lower OS rates than the CIMP-low (CIMP-L) group (P = 0.041). Of the six CIMP markers, ACAN alone was significantly associated with patient survival. CIMP predicted the risk of progression independently of clinicopathological variables and enables the stratification of pulmonary adenocarcinoma patients, particularly among stage I cases." @default.
• W2258250979 created "2016-06-24" @default.
• W2258250979 creator A5015436553 @default.
• W2258250979 creator A5019571637 @default.
• W2258250979 creator A5023416376 @default.
• W2258250979 creator A5044079996 @default.
• W2258250979 creator A5045586849 @default.
• W2258250979 creator A5071697200 @default.
• W2258250979 creator A5075392719 @default.
• W2258250979 date "2016-02-11" @default.
• W2258250979 modified "2023-09-23" @default.
• W2258250979 title "Association between the CpG island methylator phenotype and its prognostic significance in primary pulmonary adenocarcinoma" @default.
• W2258250979 cites W1965262464 @default.
• W2258250979 cites W1979538859 @default.
• W2258250979 cites W1981296068 @default.
• W2258250979 cites W1981564930 @default.
• W2258250979 cites W1990393963 @default.
• W2258250979 cites W1993312546 @default.
• W2258250979 cites W1998072168 @default.
• W2258250979 cites W1999796508 @default.
• W2258250979 cites W2001261684 @default.
• W2258250979 cites W2002575472 @default.
• W2258250979 cites W2012815363 @default.
• W2258250979 cites W2014211009 @default.
• W2258250979 cites W2021374459 @default.
• W2258250979 cites W2024807114 @default.
• W2258250979 cites W2038087250 @default.
• W2258250979 cites W2050249255 @default.
• W2258250979 cites W2051637735 @default.
• W2258250979 cites W2057668517 @default.
• W2258250979 cites W2071563896 @default.
• W2258250979 cites W2075744925 @default.
• W2258250979 cites W2076102215 @default.
• W2258250979 cites W2086294283 @default.
• W2258250979 cites W2087065324 @default.
• W2258250979 cites W2104504726 @default.
• W2258250979 cites W2110697049 @default.
• W2258250979 cites W2110845635 @default.
• W2258250979 cites W2114855342 @default.
• W2258250979 cites W2118019849 @default.
• W2258250979 cites W2119424848 @default.
• W2258250979 cites W2121203184 @default.
• W2258250979 cites W2127342594 @default.
• W2258250979 cites W2127443176 @default.
• W2258250979 cites W2128146359 @default.
• W2258250979 cites W2136207344 @default.
• W2258250979 cites W2137021232 @default.
• W2258250979 cites W2138297714 @default.
• W2258250979 cites W2147415859 @default.
• W2258250979 cites W2169903102 @default.
• W2258250979 cites W2180481128 @default.
• W2258250979 cites W4232719563 @default.
• W2258250979 doi "https://doi.org/10.1007/s13277-016-4932-2" @default.
• W2258250979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26867769" @default.
• W2258250979 hasPublicationYear "2016" @default.
• W2258250979 type Work @default.
• W2258250979 sameAs 2258250979 @default.
• W2258250979 citedByCount "8" @default.
• W2258250979 countsByYear W22582509792016 @default.
• W2258250979 countsByYear W22582509792017 @default.
• W2258250979 countsByYear W22582509792019 @default.
• W2258250979 countsByYear W22582509792020 @default.
• W2258250979 countsByYear W22582509792022 @default.
• W2258250979 countsByYear W22582509792023 @default.
• W2258250979 crossrefType "journal-article" @default.
• W2258250979 hasAuthorship W2258250979A5015436553 @default.
• W2258250979 hasAuthorship W2258250979A5019571637 @default.
• W2258250979 hasAuthorship W2258250979A5023416376 @default.
• W2258250979 hasAuthorship W2258250979A5044079996 @default.
• W2258250979 hasAuthorship W2258250979A5045586849 @default.
• W2258250979 hasAuthorship W2258250979A5071697200 @default.
• W2258250979 hasAuthorship W2258250979A5075392719 @default.
• W2258250979 hasConcept C104317684 @default.
• W2258250979 hasConcept C121608353 @default.
• W2258250979 hasConcept C126322002 @default.
• W2258250979 hasConcept C140173407 @default.
• W2258250979 hasConcept C142724271 @default.
• W2258250979 hasConcept C143998085 @default.
• W2258250979 hasConcept C146357865 @default.
• W2258250979 hasConcept C150194340 @default.
• W2258250979 hasConcept C151730666 @default.
• W2258250979 hasConcept C190727270 @default.
• W2258250979 hasConcept C2776256026 @default.
• W2258250979 hasConcept C2781182431 @default.
• W2258250979 hasConcept C33288867 @default.
• W2258250979 hasConcept C502942594 @default.
• W2258250979 hasConcept C54355233 @default.
• W2258250979 hasConcept C71924100 @default.
• W2258250979 hasConcept C86803240 @default.
• W2258250979 hasConceptScore W2258250979C104317684 @default.
• W2258250979 hasConceptScore W2258250979C121608353 @default.
• W2258250979 hasConceptScore W2258250979C126322002 @default.
• W2258250979 hasConceptScore W2258250979C140173407 @default.
• W2258250979 hasConceptScore W2258250979C142724271 @default.
• W2258250979 hasConceptScore W2258250979C143998085 @default.
• W2258250979 hasConceptScore W2258250979C146357865 @default.
• W2258250979 hasConceptScore W2258250979C150194340 @default.
• W2258250979 hasConceptScore W2258250979C151730666 @default.

• next