Matches in SemOpenAlex for { <https://semopenalex.org/work/W2258276102> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2258276102 abstract "ABSTRACT Aim: Cancer treatment has rapidly evolved in the last decades. Research is mainly directed towards the development of targeted treatments based on individual patient and tumor characteristics. A major recent focus has been the use of sequencing tests that focus on targetable gene alterations. Comprehensive cancer genomic testing using Next-Generation Sequencing (NGS) technology is a very fast and efficient tool which identifies a large number of alterations, some of which may prove to be an important aid in therapeutic decision-making. Many challenges exist in the transition of these technologies from research tool to clinical practice. We aimed to investigate the effectiveness of the current NGS technology as an aid in the oncologic treatment at our institution. Methods: We retrospectively evaluated a cohort of 75 cases of patients with solid tumors treated from Nov. 11 until Feb. 14, who had their tumors sent for a commercially available sequencing assay that utilizes clinical grade NGS. We analyzed all patients for the identification of targetable gene alterations, and whether this result led to a change in treatment and final outcome. Results: Sixty-six patients (88%) were eligible for our analysis (47% female). Sixty-two (94%) had an identifiable mutation, and 11 (17%) received treatment directed by the NGS result. Seven of these 11 patients (63%) had their tumor analyzed by specimens from metastatic sites. Only one patient had a significant tumor response, which was achieved after 2 months of directed treatment, with disease progression 4 months later. The median number of treatment lines prior to the NGS test was 3. Conclusions: Current technology already allows us to identify a large number of mutated genes in cancer specimens. However, most of those mutations are not yet drugable. Our results were somewhat disappointing, with less than 10% response among those few who could receive the directed therapy. However, it is important to note that ours was a heavily pretreated population, and that a significant number of the mutations identified might not be real drivers to the tumor growth. The results of our study suggest that the NGS test is still largely investigational, and that its use as a rescue tool for heavily pretreated patients remains questionable. Disclosure: All authors have declared no conflicts of interest." @default.
- W2258276102 created "2016-06-24" @default.
- W2258276102 creator A5002265279 @default.
- W2258276102 creator A5007616533 @default.
- W2258276102 creator A5009974709 @default.
- W2258276102 creator A5011868227 @default.
- W2258276102 creator A5015896808 @default.
- W2258276102 creator A5030091305 @default.
- W2258276102 creator A5041246775 @default.
- W2258276102 creator A5066337859 @default.
- W2258276102 creator A5067275140 @default.
- W2258276102 creator A5072207853 @default.
- W2258276102 creator A5075080955 @default.
- W2258276102 creator A5091046757 @default.
- W2258276102 date "2014-09-01" @default.
- W2258276102 modified "2023-09-29" @default.
- W2258276102 title "Next Generation Sequencing. a Key in Search of Locks?" @default.
- W2258276102 doi "https://doi.org/10.1093/annonc/mdu358.52" @default.
- W2258276102 hasPublicationYear "2014" @default.
- W2258276102 type Work @default.
- W2258276102 sameAs 2258276102 @default.
- W2258276102 citedByCount "0" @default.
- W2258276102 crossrefType "journal-article" @default.
- W2258276102 hasAuthorship W2258276102A5002265279 @default.
- W2258276102 hasAuthorship W2258276102A5007616533 @default.
- W2258276102 hasAuthorship W2258276102A5009974709 @default.
- W2258276102 hasAuthorship W2258276102A5011868227 @default.
- W2258276102 hasAuthorship W2258276102A5015896808 @default.
- W2258276102 hasAuthorship W2258276102A5030091305 @default.
- W2258276102 hasAuthorship W2258276102A5041246775 @default.
- W2258276102 hasAuthorship W2258276102A5066337859 @default.
- W2258276102 hasAuthorship W2258276102A5067275140 @default.
- W2258276102 hasAuthorship W2258276102A5072207853 @default.
- W2258276102 hasAuthorship W2258276102A5075080955 @default.
- W2258276102 hasAuthorship W2258276102A5091046757 @default.
- W2258276102 hasBestOaLocation W22582761021 @default.
- W2258276102 hasConcept C104317684 @default.
- W2258276102 hasConcept C121608353 @default.
- W2258276102 hasConcept C126322002 @default.
- W2258276102 hasConcept C141231307 @default.
- W2258276102 hasConcept C143998085 @default.
- W2258276102 hasConcept C185592680 @default.
- W2258276102 hasConcept C2779974597 @default.
- W2258276102 hasConcept C2994067223 @default.
- W2258276102 hasConcept C512399662 @default.
- W2258276102 hasConcept C51679486 @default.
- W2258276102 hasConcept C55493867 @default.
- W2258276102 hasConcept C60644358 @default.
- W2258276102 hasConcept C71924100 @default.
- W2258276102 hasConcept C72563966 @default.
- W2258276102 hasConcept C86803240 @default.
- W2258276102 hasConceptScore W2258276102C104317684 @default.
- W2258276102 hasConceptScore W2258276102C121608353 @default.
- W2258276102 hasConceptScore W2258276102C126322002 @default.
- W2258276102 hasConceptScore W2258276102C141231307 @default.
- W2258276102 hasConceptScore W2258276102C143998085 @default.
- W2258276102 hasConceptScore W2258276102C185592680 @default.
- W2258276102 hasConceptScore W2258276102C2779974597 @default.
- W2258276102 hasConceptScore W2258276102C2994067223 @default.
- W2258276102 hasConceptScore W2258276102C512399662 @default.
- W2258276102 hasConceptScore W2258276102C51679486 @default.
- W2258276102 hasConceptScore W2258276102C55493867 @default.
- W2258276102 hasConceptScore W2258276102C60644358 @default.
- W2258276102 hasConceptScore W2258276102C71924100 @default.
- W2258276102 hasConceptScore W2258276102C72563966 @default.
- W2258276102 hasConceptScore W2258276102C86803240 @default.
- W2258276102 hasLocation W22582761021 @default.
- W2258276102 hasOpenAccess W2258276102 @default.
- W2258276102 hasPrimaryLocation W22582761021 @default.
- W2258276102 hasRelatedWork W1849015182 @default.
- W2258276102 hasRelatedWork W2030070643 @default.
- W2258276102 hasRelatedWork W2076647600 @default.
- W2258276102 hasRelatedWork W2097373499 @default.
- W2258276102 hasRelatedWork W2135449254 @default.
- W2258276102 hasRelatedWork W2267629394 @default.
- W2258276102 hasRelatedWork W2336636428 @default.
- W2258276102 hasRelatedWork W2342981091 @default.
- W2258276102 hasRelatedWork W2576785370 @default.
- W2258276102 hasRelatedWork W2729136634 @default.
- W2258276102 hasRelatedWork W2758816105 @default.
- W2258276102 hasRelatedWork W2787106344 @default.
- W2258276102 hasRelatedWork W2793463154 @default.
- W2258276102 hasRelatedWork W2904572436 @default.
- W2258276102 hasRelatedWork W3044002837 @default.
- W2258276102 hasRelatedWork W3082732368 @default.
- W2258276102 hasRelatedWork W3170444564 @default.
- W2258276102 hasRelatedWork W3184845635 @default.
- W2258276102 hasRelatedWork W3187496453 @default.
- W2258276102 hasRelatedWork W3197311690 @default.
- W2258276102 isParatext "false" @default.
- W2258276102 isRetracted "false" @default.
- W2258276102 magId "2258276102" @default.
- W2258276102 workType "article" @default.