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- W2258293976 abstract "Background: N-Methyl-D-Aspartate Receptor (NMDAR) mediated central sensitisation of the cough reflex may play a role in chronic cough. Memantine, a use-dependent NMDAR antagonist, has been shown to be an effective anti-tussive in animal models. It is well-tolerated in Alzheimer9s disease. Aim: To explore the efficacy and tolerability of oral memantine in patients with refractory chronic cough. Methods: 14 subjects (13 women, mean age 58yrs) received escalating doses of memantine; 10mg OD initially, titrated weekly to 40mg OD or maximum tolerated dose. Daytime cough frequency (c/h) (VitaloJAK ™ ) and cough quality of life (Cough Quality of Life Questionnaire, CQLQ) were assessed at baseline and after 4 weeks of maximum tolerated dose, earlier if not tolerated. Results: Memantine did not significantly improve cough. Geometric mean daytime cough rate was 41.1 c/h (95%CI 22.9–73.8) at baseline vs. 30.9 c/h (95%CI 15.6–61.2) with memantine, p=0.141; median change -17.3% (range -73.6% to +115%), see Figure 1. CQLQ scores remained stable (-2.6, p=0.4). For the majority of subjects (n=10, 71.4%) 10 mg was the maximum tolerated dose, with 2 subjects (14.3%) on 20 mg and 2 (14.3%) on 30 mg. Main adverse events limiting dose were dizziness (71%), tiredness (43%) and drowsiness (36%). Conclusions: Memantine is poorly tolerated by chronic cough patients and its efficacy as an anti-tussive disappointing." @default.
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- W2258293976 date "2014-09-01" @default.
- W2258293976 modified "2023-09-23" @default.
- W2258293976 title "An open-label pilot study of memantine, an N-methyl-D-aspartate receptor antagonist in chronic cough" @default.
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