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• W2258328145 abstract "Members of the ubiquitous COX11 (cytochrome c oxidase 11) protein family are involved in copper delivery to the COX complex. In this work, we characterize the Arabidopsis thaliana COX11 homolog (encoded by locus At1g02410). Western blot analyses and confocal microscopy identified Arabidopsis COX11 as an integral mitochondrial protein. Despite sharing high sequence and structural similarities, the Arabidopsis COX11 is not able to functionally replace the Saccharomyces cerevisiae COX11 homolog. Nevertheless, further analysis confirmed the hypothesis that Arabidopsis COX11 is essential for COX activity. Disturbance of COX11 expression through knockdown (KD) or overexpression (OE) affected COX activity. In KD lines, the activity was reduced by ~50%, resulting in root growth inhibition, smaller rosettes and leaf curling. In OE lines, the reduction was less pronounced (~80% of the wild type), still resulting in root growth inhibition. Additionally, pollen germination was impaired in COX11 KD and OE plants. This effect on pollen germination can only partially be attributed to COX deficiency and may indicate a possible auxiliary role of COX11 in ROS metabolism. In agreement with its role in energy production, the COX11 promoter is highly active in cells and tissues with high-energy demand for example shoot and root meristems or vascular tissues of source and sink organs. In COX11 KD lines, the expression of the plasma-membrane copper transporter COPT2 and of several copper chaperones was upregulated, indicative of a retrograde signaling pathway pertinent to copper homeostasis. Based on our data, we postulate that COX11 is a mitochondrial chaperone, which plays an important role for plant growth and pollen germination as essential COX complex assembly factor." @default.
• W2258328145 created "2016-06-24" @default.
• W2258328145 creator A5006170744 @default.
• W2258328145 creator A5015699850 @default.
• W2258328145 creator A5055624846 @default.
• W2258328145 creator A5071550297 @default.
• W2258328145 date "2015-12-18" @default.
• W2258328145 modified "2023-10-18" @default.
• W2258328145 title "The Arabidopsis COX11 Homolog is Essential for Cytochrome c Oxidase Activity" @default.
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• W2258328145 doi "https://doi.org/10.3389/fpls.2015.01091" @default.
• W2258328145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4683207" @default.
• W2258328145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26734017" @default.
• W2258328145 hasPublicationYear "2015" @default.
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