Matches in SemOpenAlex for { <https://semopenalex.org/work/W2258400808> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2258400808 endingPage "51" @default.
- W2258400808 startingPage "48" @default.
- W2258400808 abstract "Objective To establish the model of pancreatoduodenal transplantation in pigs with enteric drainage （ED） and portal venous drainage （PVD）. Methods Forty hybrid landraces were randomized into the donor group and recipient group. Pancreatoduodenal allotransplantation was then performed. The donor pigs were perfused via abdominal aorta without clamping the portal venous outflow with UW solution at 80- 100 crnH20 after heparinization. Whole pancreatoduodenal graft was harvested with segments of abdominal aorta and portal vein and shaped under cold UW solution. Then the end-to-end anastomosis was performed with the donor iliac artery bifurcation Y graft to the recipient superior mesenteric arteries and celiac artery. Furthermore, type Ⅰ diabetes model was established by removal of the recipient pancreas. The venous anastomosis was reconstructed between the donor portal vein and the recipient superior mesenteric vein. Meanwhile, the end-to-side anastomosis was performed with the donor common iliac artery bifurcation Y graft to the recipient abdominal aorta and the side-to-side intestinal anastomosis was done between the donor duodenum and the recipient jejunum. External jugular vein was intubated for transfusion. The levels of sugar, insulin and glucagons in blood were determined during the operation and 1, 3, 5 and 7 d after the operation. Results Twenty pigs in the recipient group received pancreatoduodenal allotransplantation. One died from complication of anesthesia. The successful rate was 95.6%. Operative complications occurred in 3 pigs, in which phlebothrombosis accounted for 4. 6%, duodenojejunal anastomotic leakage for 4. 6%. The blood level of sugar decreased and those of insulin and glucagons increased within 30 min and recovered on the 2nd d after removal of the pancreas. Rejection occurred on the 1st d and reached the worst level on the 7th d after transplantation without the changes in blood levels of insulin and glucagons and symptoms of rejection. Conclusions Pancreatoduodenal transplantation in pigs can be used to treat type Ⅰ diabetes. ED and PVD can keep the endocrine function. The technique of duodenal transplantation with ED and PVD may pave the way for further development of pancreatic transplantation in clinical practice.Key words: Transplantation homologous; Pancreas; Operation; Animal model" @default.
- W2258400808 created "2016-06-24" @default.
- W2258400808 creator A5032261006 @default.
- W2258400808 creator A5051901054 @default.
- W2258400808 creator A5065529269 @default.
- W2258400808 creator A5077284329 @default.
- W2258400808 creator A5079278011 @default.
- W2258400808 creator A5084999509 @default.
- W2258400808 date "2007-01-28" @default.
- W2258400808 modified "2023-09-25" @default.
- W2258400808 title "Whole pancreatoduodenal allotransplantation model with jejunum drainage and portal vein drainage for treatment of type I diabetes in pigs" @default.
- W2258400808 doi "https://doi.org/10.3760/cma.j.issn.1007-8118.2007.01.016" @default.
- W2258400808 hasPublicationYear "2007" @default.
- W2258400808 type Work @default.
- W2258400808 sameAs 2258400808 @default.
- W2258400808 citedByCount "0" @default.
- W2258400808 crossrefType "journal-article" @default.
- W2258400808 hasAuthorship W2258400808A5032261006 @default.
- W2258400808 hasAuthorship W2258400808A5051901054 @default.
- W2258400808 hasAuthorship W2258400808A5065529269 @default.
- W2258400808 hasAuthorship W2258400808A5077284329 @default.
- W2258400808 hasAuthorship W2258400808A5079278011 @default.
- W2258400808 hasAuthorship W2258400808A5084999509 @default.
- W2258400808 hasConcept C126322002 @default.
- W2258400808 hasConcept C141071460 @default.
- W2258400808 hasConcept C2776366702 @default.
- W2258400808 hasConcept C2776809568 @default.
- W2258400808 hasConcept C2777202286 @default.
- W2258400808 hasConcept C2777561873 @default.
- W2258400808 hasConcept C2777575454 @default.
- W2258400808 hasConcept C2777956836 @default.
- W2258400808 hasConcept C2779033008 @default.
- W2258400808 hasConcept C2779980429 @default.
- W2258400808 hasConcept C2780520971 @default.
- W2258400808 hasConcept C2781046184 @default.
- W2258400808 hasConcept C2911091166 @default.
- W2258400808 hasConcept C71924100 @default.
- W2258400808 hasConcept C8443397 @default.
- W2258400808 hasConceptScore W2258400808C126322002 @default.
- W2258400808 hasConceptScore W2258400808C141071460 @default.
- W2258400808 hasConceptScore W2258400808C2776366702 @default.
- W2258400808 hasConceptScore W2258400808C2776809568 @default.
- W2258400808 hasConceptScore W2258400808C2777202286 @default.
- W2258400808 hasConceptScore W2258400808C2777561873 @default.
- W2258400808 hasConceptScore W2258400808C2777575454 @default.
- W2258400808 hasConceptScore W2258400808C2777956836 @default.
- W2258400808 hasConceptScore W2258400808C2779033008 @default.
- W2258400808 hasConceptScore W2258400808C2779980429 @default.
- W2258400808 hasConceptScore W2258400808C2780520971 @default.
- W2258400808 hasConceptScore W2258400808C2781046184 @default.
- W2258400808 hasConceptScore W2258400808C2911091166 @default.
- W2258400808 hasConceptScore W2258400808C71924100 @default.
- W2258400808 hasConceptScore W2258400808C8443397 @default.
- W2258400808 hasIssue "01" @default.
- W2258400808 hasLocation W22584008081 @default.
- W2258400808 hasOpenAccess W2258400808 @default.
- W2258400808 hasPrimaryLocation W22584008081 @default.
- W2258400808 hasRelatedWork W1975319919 @default.
- W2258400808 hasRelatedWork W1979731788 @default.
- W2258400808 hasRelatedWork W2040710727 @default.
- W2258400808 hasRelatedWork W2055504656 @default.
- W2258400808 hasRelatedWork W2348244110 @default.
- W2258400808 hasRelatedWork W2353545514 @default.
- W2258400808 hasRelatedWork W2361411845 @default.
- W2258400808 hasRelatedWork W2363425059 @default.
- W2258400808 hasRelatedWork W2365016186 @default.
- W2258400808 hasRelatedWork W2367098306 @default.
- W2258400808 hasRelatedWork W2368005390 @default.
- W2258400808 hasRelatedWork W2378279651 @default.
- W2258400808 hasRelatedWork W2380104999 @default.
- W2258400808 hasRelatedWork W2386504182 @default.
- W2258400808 hasRelatedWork W2388351798 @default.
- W2258400808 hasRelatedWork W2389964263 @default.
- W2258400808 hasRelatedWork W2404485230 @default.
- W2258400808 hasRelatedWork W240535800 @default.
- W2258400808 hasRelatedWork W3032093563 @default.
- W2258400808 hasRelatedWork W3032588303 @default.
- W2258400808 hasVolume "13" @default.
- W2258400808 isParatext "false" @default.
- W2258400808 isRetracted "false" @default.
- W2258400808 magId "2258400808" @default.
- W2258400808 workType "article" @default.