FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2258532034> ?p ?o ?g. }

• W2258532034 endingPage "e010002" @default.
• W2258532034 startingPage "e010002" @default.
• W2258532034 abstract "To measure test accuracy of non-invasive prenatal testing (NIPT) for Down, Edwards and Patau syndromes using cell-free fetal DNA and identify factors affecting accuracy.Systematic review and meta-analysis of published studies.PubMed, Ovid Medline, Ovid Embase and the Cochrane Library published from 1997 to 9 February 2015, followed by weekly autoalerts until 1 April 2015.English language journal articles describing case-control studies with ≥ 15 trisomy cases or cohort studies with ≥ 50 pregnant women who had been given NIPT and a reference standard.41, 37 and 30 studies of 2012 publications retrieved were included in the review for Down, Edwards and Patau syndromes. Quality appraisal identified high risk of bias in included studies, funnel plots showed evidence of publication bias. Pooled sensitivity was 99.3% (95% CI 98.9% to 99.6%) for Down, 97.4% (95.8% to 98.4%) for Edwards, and 97.4% (86.1% to 99.6%) for Patau syndrome. The pooled specificity was 99.9% (99.9% to 100%) for all three trisomies. In 100,000 pregnancies in the general obstetric population we would expect 417, 89 and 40 cases of Downs, Edwards and Patau syndromes to be detected by NIPT, with 94, 154 and 42 false positive results. Sensitivity was lower in twin than singleton pregnancies, reduced by 9% for Down, 28% for Edwards and 22% for Patau syndrome. Pooled sensitivity was also lower in the first trimester of pregnancy, in studies in the general obstetric population, and in cohort studies with consecutive enrolment.NIPT using cell-free fetal DNA has very high sensitivity and specificity for Down syndrome, with slightly lower sensitivity for Edwards and Patau syndrome. However, it is not 100% accurate and should not be used as a final diagnosis for positive cases.CRD42014014947." @default.
• W2258532034 created "2016-06-24" @default.
• W2258532034 creator A5024423524 @default.
• W2258532034 creator A5025456912 @default.
• W2258532034 creator A5031812482 @default.
• W2258532034 creator A5046335423 @default.
• W2258532034 creator A5066162117 @default.
• W2258532034 creator A5068522936 @default.
• W2258532034 creator A5075245317 @default.
• W2258532034 creator A5084035555 @default.
• W2258532034 creator A5086633752 @default.
• W2258532034 date "2016-01-01" @default.
• W2258532034 modified "2023-10-13" @default.
• W2258532034 title "Accuracy of non-invasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis" @default.
• W2258532034 cites W1499684505 @default.
• W2258532034 cites W1516928463 @default.
• W2258532034 cites W1583962399 @default.
• W2258532034 cites W1596268237 @default.
• W2258532034 cites W1643140812 @default.
• W2258532034 cites W1700022468 @default.
• W2258532034 cites W1735697487 @default.
• W2258532034 cites W1973593314 @default.
• W2258532034 cites W1977715723 @default.
• W2258532034 cites W1984290204 @default.
• W2258532034 cites W1986835179 @default.
• W2258532034 cites W1989285734 @default.
• W2258532034 cites W1995015678 @default.
• W2258532034 cites W2019824795 @default.
• W2258532034 cites W2020488794 @default.
• W2258532034 cites W2023879574 @default.
• W2258532034 cites W2023887451 @default.
• W2258532034 cites W2026417450 @default.
• W2258532034 cites W2035972555 @default.
• W2258532034 cites W2049706382 @default.
• W2258532034 cites W2054519798 @default.
• W2258532034 cites W2058265281 @default.
• W2258532034 cites W2070056897 @default.
• W2258532034 cites W2070930343 @default.
• W2258532034 cites W2077896602 @default.
• W2258532034 cites W2078927009 @default.
• W2258532034 cites W2083518637 @default.
• W2258532034 cites W2083904331 @default.
• W2258532034 cites W2085240060 @default.
• W2258532034 cites W2086358893 @default.
• W2258532034 cites W2087184623 @default.
• W2258532034 cites W2090779839 @default.
• W2258532034 cites W2092926517 @default.
• W2258532034 cites W2098964174 @default.
• W2258532034 cites W2099650901 @default.
• W2258532034 cites W2100280977 @default.
• W2258532034 cites W2107638293 @default.
• W2258532034 cites W2108641027 @default.
• W2258532034 cites W2109338675 @default.
• W2258532034 cites W2109816924 @default.
• W2258532034 cites W2112554208 @default.
• W2258532034 cites W2118645304 @default.
• W2258532034 cites W2126727011 @default.
• W2258532034 cites W2129125677 @default.
• W2258532034 cites W2130056558 @default.
• W2258532034 cites W2130603082 @default.
• W2258532034 cites W2132238722 @default.
• W2258532034 cites W2134164600 @default.
• W2258532034 cites W2134744749 @default.
• W2258532034 cites W2137753678 @default.
• W2258532034 cites W2139926668 @default.
• W2258532034 cites W2142062901 @default.
• W2258532034 cites W2144067971 @default.
• W2258532034 cites W2144191591 @default.
• W2258532034 cites W2152763894 @default.
• W2258532034 cites W2152918043 @default.
• W2258532034 cites W2155553535 @default.
• W2258532034 cites W2156318404 @default.
• W2258532034 cites W2168219608 @default.
• W2258532034 cites W2169279496 @default.
• W2258532034 cites W2156496744 @default.
• W2258532034 doi "https://doi.org/10.1136/bmjopen-2015-010002" @default.
• W2258532034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4735304" @default.
• W2258532034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26781507" @default.
• W2258532034 hasPublicationYear "2016" @default.
• W2258532034 type Work @default.
• W2258532034 sameAs 2258532034 @default.
• W2258532034 citedByCount "272" @default.
• W2258532034 countsByYear W22585320342016 @default.
• W2258532034 countsByYear W22585320342017 @default.
• W2258532034 countsByYear W22585320342018 @default.
• W2258532034 countsByYear W22585320342019 @default.
• W2258532034 countsByYear W22585320342020 @default.
• W2258532034 countsByYear W22585320342021 @default.
• W2258532034 countsByYear W22585320342022 @default.
• W2258532034 countsByYear W22585320342023 @default.
• W2258532034 crossrefType "journal-article" @default.
• W2258532034 hasAuthorship W2258532034A5024423524 @default.
• W2258532034 hasAuthorship W2258532034A5025456912 @default.
• W2258532034 hasAuthorship W2258532034A5031812482 @default.
• W2258532034 hasAuthorship W2258532034A5046335423 @default.
• W2258532034 hasAuthorship W2258532034A5066162117 @default.
• W2258532034 hasAuthorship W2258532034A5068522936 @default.
• W2258532034 hasAuthorship W2258532034A5075245317 @default.

• next