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• W2258563586 abstract "Abnormal global DNA methylation levels are associated with many diseases. In this study, we examined long interspersed nuclear elements-1 (LINE-1) methylation as a biomarker for abnormal global DNA methylation and aldosterone-producing adenoma (APA).Tissues from 25 APA and 6 normal adrenal glands (NAs) were analyzed for LINE-1 methylation by real-time methylation-specific polymerase chain reaction. The estimated LINE-1 methylation level was then tested for correlation with the clinicopathologic parameters of APA patients.The methylation index (MI) level for LINE-1 was 0.91 in NA samples and 0.77 in APA samples (P < 0.001). For the APA samples, there were no statistical correlations between the MI level and various clinicopathologic parameters such as gender (P = 0.07).LINE-1 methylation is significantly lower in APA samples than in NA samples. LINE-1 methylation is not correlated with the clinical characteristics of APA." @default.
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• W2258563586 date "2014-01-01" @default.
• W2258563586 modified "2023-09-25" @default.
• W2258563586 title "Decreased LINE-1 methylation levels in aldosterone-producing adenoma." @default.
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• W2258563586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4129024" @default.
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