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- W2258698935 abstract "ABSTRACT The effect of extracellular cobalt on the frequency of miniature excitatory post-synaptic potentials (MEPSPs) was studied in cockroach leg muscle fibres that had been depolarized with 20·8 mm-K saline. Cobalt ions had a dual effect on the spontaneous release of transmitter, an inhibitory action being followed by an acceleratory. A reciprocal relationship between Ca2+ and Co2+ was found for both the inhibitory and acceleratory effects. The equilibrium dissociation constant for Co2+ as a competitive antagonist of spontaneous release ranged from 0·4 to 0·65 mm. It is concluded that Co2+ is much more potent than Mg2+ in suppressing spontaneous transmitter release at the insect neuromuscular junction. The antagonism by extracellular Co2+ appears to occur only at the external surface site on the terminal membrane." @default.
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- W2258698935 date "1982-06-01" @default.
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- W2258698935 title "A Dual Effect of Cobalt Ions on the Spontaneous Release of Transmitter At Insect Motor Nerve Terminals" @default.
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- W2258698935 doi "https://doi.org/10.1242/jeb.98.1.353" @default.
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