FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2258719593> ?p ?o ?g. }

• W2258719593 abstract "Graphene oxide (GO) is a promising nanomaterial for application in a variety of biomedical fields, including neuro-oncology, neuroimaging, neuroregeneration and drug delivery. Microglia are the central macrophage-like cells critically involved in neuroimmunity. However, the interaction between GO and microglia remained mostly unknown. The present study investigated the influence of GO on the production of proinflammatory cytokines by microglia. Primary murine microglial cells were treated with GO (1–25 μg/mL) followed by stimulation with lipopolysaccharide (LPS) for 24 h. The cell viability was measured by spectrophotometry using AlamarBlueⓇ. The levels of interleukin (IL)-1β and tumor necrosis factor (TNF)-α in the supernatants were measured by enzyme-linked immunosorbent assay (ELISA). The IL-1β converting enzyme (ICE) activity was measured using a specific fluorescent substrate. The activity of cathepsin B and the lysosomal permeability and alkalinity were determined by flow cytometry. Treatment with GO did not affect cell viability, but significantly suppressed the production of IL-1β. In contrast, the production of TNF-α was unaltered. In addition, the lysosomal permeability and alkalinity in microglia treated with GO were increased, whereas the activity of cathepsin B and ICE was decreased. Collectively, these results demonstrated that exposure to GO differentially affected the production of proinflammatory cytokines, which is associated with the modulation of the lysosomal pathway of cytokines processing." @default.
• W2258719593 created "2016-06-24" @default.
• W2258719593 creator A5020508750 @default.
• W2258719593 creator A5037202306 @default.
• W2258719593 creator A5051815699 @default.
• W2258719593 creator A5062895509 @default.
• W2258719593 date "2015-09-01" @default.
• W2258719593 modified "2023-09-29" @default.
• W2258719593 title "A DIFFERENTIAL EFFECT OF GRAPHENE OXIDE ON THE PRODUCTION OF PROINFLAMMATORY CYTOKINES BY MURINE MICROGLIA" @default.
• W2258719593 cites W1967850823 @default.
• W2258719593 cites W1969533704 @default.
• W2258719593 cites W1972708772 @default.
• W2258719593 cites W1977604451 @default.
• W2258719593 cites W1997288069 @default.
• W2258719593 cites W2010226025 @default.
• W2258719593 cites W2020079600 @default.
• W2258719593 cites W2022394525 @default.
• W2258719593 cites W2025531839 @default.
• W2258719593 cites W2027237872 @default.
• W2258719593 cites W2032587845 @default.
• W2258719593 cites W2037794305 @default.
• W2258719593 cites W2048294524 @default.
• W2258719593 cites W2056368730 @default.
• W2258719593 cites W2057330747 @default.
• W2258719593 cites W2070177926 @default.
• W2258719593 cites W2077637800 @default.
• W2258719593 cites W2080245111 @default.
• W2258719593 cites W2080637633 @default.
• W2258719593 cites W2081572333 @default.
• W2258719593 cites W2109759840 @default.
• W2258719593 cites W2121491039 @default.
• W2258719593 cites W2121990753 @default.
• W2258719593 cites W2126941192 @default.
• W2258719593 cites W2131539142 @default.
• W2258719593 cites W2136459729 @default.
• W2258719593 cites W2154580307 @default.
• W2258719593 cites W2154993099 @default.
• W2258719593 cites W2326443463 @default.
• W2258719593 doi "https://doi.org/10.1142/s1682648515500110" @default.
• W2258719593 hasPublicationYear "2015" @default.
• W2258719593 type Work @default.
• W2258719593 sameAs 2258719593 @default.
• W2258719593 citedByCount "1" @default.
• W2258719593 countsByYear W22587195932018 @default.
• W2258719593 crossrefType "journal-article" @default.
• W2258719593 hasAuthorship W2258719593A5020508750 @default.
• W2258719593 hasAuthorship W2258719593A5037202306 @default.
• W2258719593 hasAuthorship W2258719593A5051815699 @default.
• W2258719593 hasAuthorship W2258719593A5062895509 @default.
• W2258719593 hasConcept C134018914 @default.
• W2258719593 hasConcept C164027704 @default.
• W2258719593 hasConcept C173633252 @default.
• W2258719593 hasConcept C17991360 @default.
• W2258719593 hasConcept C181199279 @default.
• W2258719593 hasConcept C185592680 @default.
• W2258719593 hasConcept C190283241 @default.
• W2258719593 hasConcept C203014093 @default.
• W2258719593 hasConcept C2776914184 @default.
• W2258719593 hasConcept C2778754761 @default.
• W2258719593 hasConcept C2779830541 @default.
• W2258719593 hasConcept C28021979 @default.
• W2258719593 hasConcept C519581460 @default.
• W2258719593 hasConcept C53227056 @default.
• W2258719593 hasConcept C55493867 @default.
• W2258719593 hasConcept C86803240 @default.
• W2258719593 hasConcept C87753298 @default.
• W2258719593 hasConcept C95444343 @default.
• W2258719593 hasConceptScore W2258719593C134018914 @default.
• W2258719593 hasConceptScore W2258719593C164027704 @default.
• W2258719593 hasConceptScore W2258719593C173633252 @default.
• W2258719593 hasConceptScore W2258719593C17991360 @default.
• W2258719593 hasConceptScore W2258719593C181199279 @default.
• W2258719593 hasConceptScore W2258719593C185592680 @default.
• W2258719593 hasConceptScore W2258719593C190283241 @default.
• W2258719593 hasConceptScore W2258719593C203014093 @default.
• W2258719593 hasConceptScore W2258719593C2776914184 @default.
• W2258719593 hasConceptScore W2258719593C2778754761 @default.
• W2258719593 hasConceptScore W2258719593C2779830541 @default.
• W2258719593 hasConceptScore W2258719593C28021979 @default.
• W2258719593 hasConceptScore W2258719593C519581460 @default.
• W2258719593 hasConceptScore W2258719593C53227056 @default.
• W2258719593 hasConceptScore W2258719593C55493867 @default.
• W2258719593 hasConceptScore W2258719593C86803240 @default.
• W2258719593 hasConceptScore W2258719593C87753298 @default.
• W2258719593 hasConceptScore W2258719593C95444343 @default.
• W2258719593 hasLocation W22587195931 @default.
• W2258719593 hasOpenAccess W2258719593 @default.
• W2258719593 hasPrimaryLocation W22587195931 @default.
• W2258719593 hasRelatedWork W1514946732 @default.
• W2258719593 hasRelatedWork W1601926208 @default.
• W2258719593 hasRelatedWork W1964141850 @default.
• W2258719593 hasRelatedWork W2017391589 @default.
• W2258719593 hasRelatedWork W2030539829 @default.
• W2258719593 hasRelatedWork W2052438611 @default.
• W2258719593 hasRelatedWork W2060647682 @default.
• W2258719593 hasRelatedWork W2113929586 @default.
• W2258719593 hasRelatedWork W2337718051 @default.
• W2258719593 hasRelatedWork W2353163157 @default.
• W2258719593 hasRelatedWork W2355368101 @default.
• W2258719593 hasRelatedWork W2381414302 @default.

• next