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- W2258775981 abstract "Caffeine is the most widely used psychostimulant worldwide. Excessive caffeine consumption induces a series of both acute and chronic biological and physiological changes that may give rise to cognitive decline, depression, fatigue, insomnia, cardiovascular changes, and headache. Chronic consumption of caffeine promotes a pro-nociceptive state of cortical hyperexcitability that can intensify a primary headache or trigger a headache due to excessive analgesic use. This review offers an in-depth analysis of the physiological mechanisms of caffeine and its relationship with headache. La cafeína es la droga psicoestimulante más ampliamente utilizada en el mundo. El exagerado consumo de cafeína induce una serie de cambios biológicos y fisiológicos de forma aguda y crónica, que se pueden traducir en déficit cognitivo, depresión, fatiga, insomnio, cambios cardiovasculares y cefalea. El consumo crónico de cafeína promueve un estado pronociceptivo y de hiperexcitabilidad cortical que puede exacerbar una cefalea primaria o desencadenar una cefalea por uso excesivo de analgésicos. El objetivo de la revisión es profundizar en los aspectos fisiológicos de la cafeína y su relación con la cefalea." @default.
- W2258775981 created "2016-06-24" @default.
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- W2258775981 date "2017-07-01" @default.
- W2258775981 modified "2023-10-17" @default.
- W2258775981 title "Caffeine and headache: specific remarks" @default.
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- W2258775981 doi "https://doi.org/10.1016/j.nrleng.2014.12.022" @default.
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