FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2258984948> ?p ?o ?g. }

• W2258984948 endingPage "2256" @default.
• W2258984948 startingPage "2246" @default.
• W2258984948 abstract "A traditional Chinese medicine, Qiliqiangxin (QLQX) has been identified to perform protective effects on myocardium energy metabolism in mice with acute myocardial infarction, though the effects of QLQX on myocardial mitochondrial biogenesis under physiological condition is still largely elusive.H9C2 cells were treated with different concentrations of QLQX (0.25, 0.5, and 1.0 µg/mL) from 6 to 48 hours. Oxidative metabolism and glycolysis were measured by oxygen consumption and extracellular acidification with XF96 analyzer (SeaHorse). Mitochondrial content and ultrastructure were assessed by Mitotracker staining, confocal microscopy, flow cytometry, and transmission electron microscopy. Mitochondrial biogenesis-related genes were measured by qRT-PCR and Western blot.H9C2 cells treated with QLQX exhibited increased glycolysis at earlier time points (6, 12, and 24 hours), while QLQX could enhance oxidative metabolism and mitochondrial uncoupling in H9C2 cells with longer duration of treatment (48 hours). QLQX also increased mitochondrial content and mitochondrial biogenesis-related gene expression levels, including 16sRNA, SSBP1, TWINKLE, TOP1MT and PLOG, with an activation of peroxisome proliferator-activated receptor coactivator 1 alpha (PGC-1α) and its downstream effectors. Silencing PGC-1α could abolish the increased mitochondrial content in H9C2 cells treated with QLQX.Our study is the first to document enhanced metabolism in cardiomyocytes treated with QLQX, which is linked to increased mitochondrial content and mitochondrial biogenesis via activation of PGC-1α." @default.
• W2258984948 created "2016-06-24" @default.
• W2258984948 creator A5005400963 @default.
• W2258984948 creator A5007717960 @default.
• W2258984948 creator A5009133589 @default.
• W2258984948 creator A5012318743 @default.
• W2258984948 creator A5024856509 @default.
• W2258984948 creator A5044316257 @default.
• W2258984948 creator A5052547525 @default.
• W2258984948 creator A5063363406 @default.
• W2258984948 creator A5079029237 @default.
• W2258984948 date "2015-01-01" @default.
• W2258984948 modified "2023-09-27" @default.
• W2258984948 title "The Metabolic Effects of Traditional Chinese Medication Qiliqiangxin on H9C2 Cardiomyocytes" @default.
• W2258984948 cites W1246257613 @default.
• W2258984948 cites W1560825800 @default.
• W2258984948 cites W1581769390 @default.
• W2258984948 cites W1841393598 @default.
• W2258984948 cites W1953780863 @default.
• W2258984948 cites W1966985989 @default.
• W2258984948 cites W1990579890 @default.
• W2258984948 cites W2000249408 @default.
• W2258984948 cites W2007013554 @default.
• W2258984948 cites W2011344898 @default.
• W2258984948 cites W2024943263 @default.
• W2258984948 cites W2044782567 @default.
• W2258984948 cites W2049312885 @default.
• W2258984948 cites W2067510473 @default.
• W2258984948 cites W2073333186 @default.
• W2258984948 cites W2075463771 @default.
• W2258984948 cites W2081703555 @default.
• W2258984948 cites W2081875625 @default.
• W2258984948 cites W2101799172 @default.
• W2258984948 cites W2101862307 @default.
• W2258984948 cites W2114767103 @default.
• W2258984948 cites W2129599634 @default.
• W2258984948 cites W2136747158 @default.
• W2258984948 cites W2137833814 @default.
• W2258984948 cites W2160476723 @default.
• W2258984948 cites W2179221816 @default.
• W2258984948 doi "https://doi.org/10.1159/000438580" @default.
• W2258984948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26618786" @default.
• W2258984948 hasPublicationYear "2015" @default.
• W2258984948 type Work @default.
• W2258984948 sameAs 2258984948 @default.
• W2258984948 citedByCount "20" @default.
• W2258984948 countsByYear W22589849482016 @default.
• W2258984948 countsByYear W22589849482017 @default.
• W2258984948 countsByYear W22589849482018 @default.
• W2258984948 countsByYear W22589849482019 @default.
• W2258984948 countsByYear W22589849482020 @default.
• W2258984948 countsByYear W22589849482021 @default.
• W2258984948 countsByYear W22589849482022 @default.
• W2258984948 countsByYear W22589849482023 @default.
• W2258984948 crossrefType "journal-article" @default.
• W2258984948 hasAuthorship W2258984948A5005400963 @default.
• W2258984948 hasAuthorship W2258984948A5007717960 @default.
• W2258984948 hasAuthorship W2258984948A5009133589 @default.
• W2258984948 hasAuthorship W2258984948A5012318743 @default.
• W2258984948 hasAuthorship W2258984948A5024856509 @default.
• W2258984948 hasAuthorship W2258984948A5044316257 @default.
• W2258984948 hasAuthorship W2258984948A5052547525 @default.
• W2258984948 hasAuthorship W2258984948A5063363406 @default.
• W2258984948 hasAuthorship W2258984948A5079029237 @default.
• W2258984948 hasBestOaLocation W22589849481 @default.
• W2258984948 hasConcept C104317684 @default.
• W2258984948 hasConcept C134018914 @default.
• W2258984948 hasConcept C153911025 @default.
• W2258984948 hasConcept C169415338 @default.
• W2258984948 hasConcept C185592680 @default.
• W2258984948 hasConcept C20251656 @default.
• W2258984948 hasConcept C24586158 @default.
• W2258984948 hasConcept C2777229759 @default.
• W2258984948 hasConcept C28859421 @default.
• W2258984948 hasConcept C553184892 @default.
• W2258984948 hasConcept C55493867 @default.
• W2258984948 hasConcept C57600042 @default.
• W2258984948 hasConcept C62231903 @default.
• W2258984948 hasConcept C86803240 @default.
• W2258984948 hasConcept C95444343 @default.
• W2258984948 hasConceptScore W2258984948C104317684 @default.
• W2258984948 hasConceptScore W2258984948C134018914 @default.
• W2258984948 hasConceptScore W2258984948C153911025 @default.
• W2258984948 hasConceptScore W2258984948C169415338 @default.
• W2258984948 hasConceptScore W2258984948C185592680 @default.
• W2258984948 hasConceptScore W2258984948C20251656 @default.
• W2258984948 hasConceptScore W2258984948C24586158 @default.
• W2258984948 hasConceptScore W2258984948C2777229759 @default.
• W2258984948 hasConceptScore W2258984948C28859421 @default.
• W2258984948 hasConceptScore W2258984948C553184892 @default.
• W2258984948 hasConceptScore W2258984948C55493867 @default.
• W2258984948 hasConceptScore W2258984948C57600042 @default.
• W2258984948 hasConceptScore W2258984948C62231903 @default.
• W2258984948 hasConceptScore W2258984948C86803240 @default.
• W2258984948 hasConceptScore W2258984948C95444343 @default.
• W2258984948 hasIssue "6" @default.
• W2258984948 hasLocation W22589849481 @default.
• W2258984948 hasLocation W22589849482 @default.

• next