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- W2259384889 abstract "Herein, we describe the development of a multilayer droplet microfluidic system for creating concentration gradients and generating microdroplets of varying composition for high-throughput biochemical and cell-based screening applications. The 3D droplet-based microfluidic device consists of multiple PDMS layers, which are used to generate logarithmic concentration gradient reagent profiles. Parallel flow focusing structures are used to form picoliter-sized droplets of defined volumes but of varying composition. As proof of concept, we demonstrate rapid enzymatic activity assays and drug cytotoxicity assays on bacteria. The 3D droplet-based microfluidic platform has the potential to allow for high-efficiency and high-throughput analysis, overcoming the structural limitations of single layer microfluidic systems." @default.
- W2259384889 created "2016-06-24" @default.
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- W2259384889 date "2015-10-26" @default.
- W2259384889 modified "2023-09-27" @default.
- W2259384889 title "3D Droplet Microfluidic Systems for High-Throughput Biological Experimentation" @default.
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- W2259384889 doi "https://doi.org/10.1021/acs.analchem.5b02402" @default.
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