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- W2259393567 abstract "Long-acting bronchodilators have been reported to have local and systemic inhibitory effects on inflammatory and allergic events while short-acting bronchodilators have been demonstrated to induce local but not systemic bronchial hyperreactivity. The long-acting bronchodilators also have been shown to have better efficacy and cause fewer adverse events compared with the short-acting forms. However, conflicting data are also presented. We conducted this study to compare the systemic anti-inflammatory and anti-allergic effects, clinical efficiency, and side effects of a short-acting bronchodilator (terbutaline sulfate) and its long-acting form (bambuterol), in mild and moderate bronchial asthma patients. Twenty nonsmokers with no history of steroid use were recruited. Participants were ref rained from using all forms of bronchodilators other than inhaled short-acting beta2-agonists for three weeks prior to beginning the study. They then received three weeks of terbutaline sulfate 2.5mg t.i.d. and three weeks of bambuterol 10mg h.s., in a randomized crossover fashion. Evaluations were performed at the end of the run-in and each drug administration period. Laboratory assessments included respiratory function, serum non-specific total immunoglobulin E(IgE), five antigen-specific IgEs, C-reactive protein, eosinophil cationic protein, blood total white cell count, neutrophil count, and eosinophil count. Clinical assessments included asthmatic symptom score, tremor score and drug side-effect score. The results showed neither drug significantly improved respiratory function or modulated allergic reactions; but both drugs, especially bambuterol, had significant inhibitory effects on the peripheral blood total white cell count, and bambuterol alone had better overall improvement in asthma symptoms. Side effects were seldom encountered and there was no significant difference between the drugs." @default.
- W2259393567 created "2016-06-24" @default.
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- W2259393567 date "1999-06-01" @default.
- W2259393567 modified "2023-09-28" @default.
- W2259393567 title "Inflammatory, Immunological and Clinical Comparisons of Short-and Long-acting Bronchodilators in Mild and Moderate Bronchial Asthma Patients" @default.
- W2259393567 doi "https://doi.org/10.30018/jeccm.199906.0003" @default.
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