FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2259432811> ?p ?o ?g. }

• W2259432811 abstract "The 5-year survival rate of patients with hepatocellular cancer (HCC) was very low because of invasion and metastasis in the early stage. Biomarkers might help predict early occurrence of invasion and metastasis. Accumulating evidence has shown that deleted in liver cancer-1 (DLC1) may be considered as a metastasis suppressor gene in numerous solid and hematological cancers. However, its prognostic role and mechanisms that regulate and coordinate these activities remain poorly understood.With the method of immunohistochemistry, the expression of DLC-1 as well as Rho A, ROCK2, moesin had been characterized in 80 HCC tissues and adjacent noncancerous tissues. The correlation between their expression and their relationships with clinicopathological characteristics of HCC were also investigated. In addition, the prognostic value of DLC1 expression within the tumor tissues was assessed by Cox regression and Kaplan-Meier analysis.DLC1 expression was significantly lower in HCC tissues than in adjacent noncancerous tissues, and DLC-1 expression was found to be negatively correlated with tumor differentiation, TNM stage and lymph node metastasis. Furthermore, DLC-1 expression was found to inversely correlate with Rho A, ROCK2 and moesin which were all highly expressed in HCC tissues. Kaplan-Meier analysis showed that significantly longer 5-year survival rate was seen in HCC patients with higher DLC1 expression, compared to those with lower expression of DLC1. Multivariate Cox proportional hazard analyses revealed that DLC1 was an independent factor affecting the overall survival probability.DLC1 could be served as a tumor suppressor gene in the progression especially in the invasion and metastasis of HCC. DLC1 perhaps played its role by regulating the expression of Rho A, ROCK2 and moesin. Evaluation of the expression of DLC-1 might be a good prognostic marker for patients with HCC." @default.
• W2259432811 created "2016-06-24" @default.
• W2259432811 creator A5004963897 @default.
• W2259432811 creator A5018503019 @default.
• W2259432811 creator A5022938518 @default.
• W2259432811 creator A5049030520 @default.
• W2259432811 creator A5066368971 @default.
• W2259432811 creator A5075421950 @default.
• W2259432811 creator A5087747758 @default.
• W2259432811 date "2016-02-04" @default.
• W2259432811 modified "2023-10-05" @default.
• W2259432811 title "DLC-1 is an independent prognostic marker and potential therapeutic target in hepatocellular cancer" @default.
• W2259432811 cites W1572102088 @default.
• W2259432811 cites W1936218825 @default.
• W2259432811 cites W1973580165 @default.
• W2259432811 cites W1976751072 @default.
• W2259432811 cites W1983059732 @default.
• W2259432811 cites W1987380845 @default.
• W2259432811 cites W2007958820 @default.
• W2259432811 cites W2018306020 @default.
• W2259432811 cites W2019175852 @default.
• W2259432811 cites W2027765716 @default.
• W2259432811 cites W2036887542 @default.
• W2259432811 cites W2037739086 @default.
• W2259432811 cites W2045253398 @default.
• W2259432811 cites W2045690932 @default.
• W2259432811 cites W2052692244 @default.
• W2259432811 cites W2059713367 @default.
• W2259432811 cites W2064367113 @default.
• W2259432811 cites W2074435907 @default.
• W2259432811 cites W2078988248 @default.
• W2259432811 cites W2081596504 @default.
• W2259432811 cites W2109328746 @default.
• W2259432811 cites W2110118771 @default.
• W2259432811 cites W2114796219 @default.
• W2259432811 cites W2123613059 @default.
• W2259432811 cites W2135959680 @default.
• W2259432811 cites W2139671993 @default.
• W2259432811 cites W2164674592 @default.
• W2259432811 cites W2168717243 @default.
• W2259432811 cites W2171365654 @default.
• W2259432811 cites W38030205 @default.
• W2259432811 doi "https://doi.org/10.1186/s13000-016-0470-x" @default.
• W2259432811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4743322" @default.
• W2259432811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26846339" @default.
• W2259432811 hasPublicationYear "2016" @default.
• W2259432811 type Work @default.
• W2259432811 sameAs 2259432811 @default.
• W2259432811 citedByCount "14" @default.
• W2259432811 countsByYear W22594328112017 @default.
• W2259432811 countsByYear W22594328112018 @default.
• W2259432811 countsByYear W22594328112019 @default.
• W2259432811 countsByYear W22594328112020 @default.
• W2259432811 countsByYear W22594328112021 @default.
• W2259432811 countsByYear W22594328112023 @default.
• W2259432811 crossrefType "journal-article" @default.
• W2259432811 hasAuthorship W2259432811A5004963897 @default.
• W2259432811 hasAuthorship W2259432811A5018503019 @default.
• W2259432811 hasAuthorship W2259432811A5022938518 @default.
• W2259432811 hasAuthorship W2259432811A5049030520 @default.
• W2259432811 hasAuthorship W2259432811A5066368971 @default.
• W2259432811 hasAuthorship W2259432811A5075421950 @default.
• W2259432811 hasAuthorship W2259432811A5087747758 @default.
• W2259432811 hasBestOaLocation W22594328111 @default.
• W2259432811 hasConcept C10515644 @default.
• W2259432811 hasConcept C121608353 @default.
• W2259432811 hasConcept C126322002 @default.
• W2259432811 hasConcept C142724271 @default.
• W2259432811 hasConcept C143998085 @default.
• W2259432811 hasConcept C146357865 @default.
• W2259432811 hasConcept C151730666 @default.
• W2259432811 hasConcept C204232928 @default.
• W2259432811 hasConcept C2778019345 @default.
• W2259432811 hasConcept C2779013556 @default.
• W2259432811 hasConcept C502942594 @default.
• W2259432811 hasConcept C50382708 @default.
• W2259432811 hasConcept C71924100 @default.
• W2259432811 hasConcept C86803240 @default.
• W2259432811 hasConceptScore W2259432811C10515644 @default.
• W2259432811 hasConceptScore W2259432811C121608353 @default.
• W2259432811 hasConceptScore W2259432811C126322002 @default.
• W2259432811 hasConceptScore W2259432811C142724271 @default.
• W2259432811 hasConceptScore W2259432811C143998085 @default.
• W2259432811 hasConceptScore W2259432811C146357865 @default.
• W2259432811 hasConceptScore W2259432811C151730666 @default.
• W2259432811 hasConceptScore W2259432811C204232928 @default.
• W2259432811 hasConceptScore W2259432811C2778019345 @default.
• W2259432811 hasConceptScore W2259432811C2779013556 @default.
• W2259432811 hasConceptScore W2259432811C502942594 @default.
• W2259432811 hasConceptScore W2259432811C50382708 @default.
• W2259432811 hasConceptScore W2259432811C71924100 @default.
• W2259432811 hasConceptScore W2259432811C86803240 @default.
• W2259432811 hasIssue "1" @default.
• W2259432811 hasLocation W22594328111 @default.
• W2259432811 hasLocation W22594328112 @default.
• W2259432811 hasLocation W22594328113 @default.
• W2259432811 hasLocation W22594328114 @default.
• W2259432811 hasOpenAccess W2259432811 @default.
• W2259432811 hasPrimaryLocation W22594328111 @default.
• W2259432811 hasRelatedWork W1499339123 @default.

• next