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• W2259446562 abstract "The reversible folding and unfolding of proteins uncovered by Anfinsen and Pauling was a landmark event. It established the primacy of the amino acid sequence in determining the functional, native state of a protein. It further set the stage for the equally remarkable discovery that proteins can possess more than one stable conformation; and that these alternative conformations, brought on by mutations or abnormal environmental conditions, can promote aggregation and a host of neurodegenerative diseases." @default.
• W2259446562 created "2016-06-24" @default.
• W2259446562 creator A5037030367 @default.
• W2259446562 date "2015-01-01" @default.
• W2259446562 modified "2023-09-23" @default.
• W2259446562 title "Protein Misfolding and Aggregation" @default.
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• W2259446562 doi "https://doi.org/10.1007/978-3-319-22117-5_4" @default.
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