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- W2259585489 abstract "Bacterial infection causes bone marrow hematopoietic activity to shift toward granulopoiesis which is a critical event for enhancing host defense. This study investigated the hematopoietic precursor cell (HPC) response to bacteremia and how alcohol affects this response. Acute alcohol intoxication was induced in Balb/c mice 30 min prior to initiation of E. coli bacteremia. Bacteremia significantly increased the number of lineage (lin)-c-kit+Sca-1+ (LKS+) cells, which was suppressed by alcohol. LKS+ cells isolated from bacteremic mice had increased CFU-GM activity compared to controls. Both enhanced proliferation of LKS+ cells as reflected by BrdU incorporation, and phenotypic inversion of lin-c-kit+Sca-1- (LKS-) cells accounted for the increase in LKS+ cells following bacteremia. Bacteremia increased plasma TNF-α, which was inhibited by alcohol. Culture of LKS- cells with TNF-α caused a dose-dependent increase in conversion of these cells to LKS+ cells, which was attenuated by alcohol. Sca-1 mRNA expression in cultured LKS- cells was up-regulated following TNF-α stimulation. E. coli clearance was impaired by alcohol, causing increased mortality in these animals. These data show that alcohol inhibits the HPC response to bacteremia which may serve as one mechanism underlying the impaired host defense in alcohol abusers with severe bacterial infections. Supported by NIH grants AA09803 and HL76100." @default.
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- W2259585489 date "2009-04-01" @default.
- W2259585489 modified "2023-10-10" @default.
- W2259585489 title "Acute alcohol intoxication inhibits the hematopoietic precursor cell response to Escherichia coli bacteremia" @default.
- W2259585489 doi "https://doi.org/10.1096/fasebj.23.1_supplement.1030.11" @default.
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