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- W2259663950 abstract "Bacitracin was administered continuously in the drinking water to four groups of growing rabbits at doses of 105, 210, 420 or 840 IU/kg body weight as a water-soluble veterinary medicinal product (Bacivet®-S) for seven consecutive days. Cecum samples were taken 0, 4, 8, 12 and 24 hours postdosing on days 3 and 7 of the treatment. These samples were analysed using liquid chromatography with tandem mass spectrometry detection (LC/MS/MS). The results show that 105 IU/kg did not expose the cecum to inhibitory concentrations and 210 IU/kg failed to maintain bactericidal levels for more than a few hours. The 420 IU/mg dose maintained bactericidal concentrations for the entire 24hour period with 2102 μg/kg as the lowest mean concentration measured over the considered period, a value close to the target Minimal Bactericidal Concentration of 1860 μg/ml estimated for bacitracin in vitro. Concentrations obtained at 840 IU/kg were far higher. These results justify a daily dose of 420 IU/kg/day in the treatment of intestinal infections where Clostridium perfringens can be isolated. In addition, after 30 days of continuous administration at 420 IU/kg body weight, blood concentrations remained below the detection limit (<37.5 μg/l). As a consequence, no residues were found (<75 μg/kg) in any edible tissue from the first day after treatment withdrawal." @default.
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- W2259663950 date "2008-01-01" @default.
- W2259663950 modified "2023-09-23" @default.
- W2259663950 title "Dose determination for Bacitracin against Clostridium perfringens using a pharmacokinetic/pharmacodynamic (PK/PD) approach. Impact on consumer safety." @default.
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