Matches in SemOpenAlex for { <https://semopenalex.org/work/W2259664588> ?p ?o ?g. }
- W2259664588 abstract "Abstract Porcine reproductive and respiratory syndrome (PRRS) has caused large economic losses in the swine industry in recent years. Current PRRS vaccines fail to effectively prevent and control this disease. Consequently, there is a need to develop new antiviral strategies. MicroRNAs play critical roles in intricate host-pathogen interaction networks, but the involvement of miRNAs during PRRS virus (PRRSV) infection is not well understood. In this study, pretreatment with miR-26a induced a significant inhibition of PRRSV replication and remission of the cytopathic effect in MARC-145 cells and this antiviral effect was sustained for at least 120 h. Luciferase reporter analysis showed that the PRRSV genome was not the target of miRNA-26a. Instead, RNA-seq analysis demonstrated that miR-26a significantly up-regulated innate anti-viral responses, including activating the type I interferon (IFN) signaling pathway and promoting the production of IFN-stimulated genes. These findings suggest that delivery of miR-26a may provide a potential strategy for anti-PRRSV therapies." @default.
- W2259664588 created "2016-06-24" @default.
- W2259664588 creator A5012009078 @default.
- W2259664588 creator A5026919394 @default.
- W2259664588 creator A5038776482 @default.
- W2259664588 creator A5049445988 @default.
- W2259664588 creator A5058867402 @default.
- W2259664588 creator A5061175474 @default.
- W2259664588 date "2015-05-27" @default.
- W2259664588 modified "2023-09-27" @default.
- W2259664588 title "Cellular microRNA miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity" @default.
- W2259664588 cites W1964822453 @default.
- W2259664588 cites W1975931383 @default.
- W2259664588 cites W1976077409 @default.
- W2259664588 cites W1976658055 @default.
- W2259664588 cites W1981513590 @default.
- W2259664588 cites W1981601884 @default.
- W2259664588 cites W1982961894 @default.
- W2259664588 cites W1997264498 @default.
- W2259664588 cites W2016801816 @default.
- W2259664588 cites W2017164093 @default.
- W2259664588 cites W2026051181 @default.
- W2259664588 cites W2034667001 @default.
- W2259664588 cites W2035509260 @default.
- W2259664588 cites W2036627785 @default.
- W2259664588 cites W2040654802 @default.
- W2259664588 cites W2048178760 @default.
- W2259664588 cites W2050850788 @default.
- W2259664588 cites W2052445951 @default.
- W2259664588 cites W2065324182 @default.
- W2259664588 cites W2076287538 @default.
- W2259664588 cites W2080416805 @default.
- W2259664588 cites W2082742317 @default.
- W2259664588 cites W2083255319 @default.
- W2259664588 cites W2094829945 @default.
- W2259664588 cites W2107496089 @default.
- W2259664588 cites W2111585311 @default.
- W2259664588 cites W2116739202 @default.
- W2259664588 cites W2123894642 @default.
- W2259664588 cites W2128048963 @default.
- W2259664588 cites W2133106116 @default.
- W2259664588 cites W2133613657 @default.
- W2259664588 cites W2135574530 @default.
- W2259664588 cites W2148276874 @default.
- W2259664588 cites W2159807040 @default.
- W2259664588 cites W2159838656 @default.
- W2259664588 cites W2159947608 @default.
- W2259664588 cites W2160102037 @default.
- W2259664588 cites W2167232191 @default.
- W2259664588 cites W2170208518 @default.
- W2259664588 cites W2171106047 @default.
- W2259664588 cites W2400338985 @default.
- W2259664588 doi "https://doi.org/10.1038/srep10651" @default.
- W2259664588 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4445041" @default.
- W2259664588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26013676" @default.
- W2259664588 hasPublicationYear "2015" @default.
- W2259664588 type Work @default.
- W2259664588 sameAs 2259664588 @default.
- W2259664588 citedByCount "42" @default.
- W2259664588 countsByYear W22596645882015 @default.
- W2259664588 countsByYear W22596645882016 @default.
- W2259664588 countsByYear W22596645882017 @default.
- W2259664588 countsByYear W22596645882018 @default.
- W2259664588 countsByYear W22596645882019 @default.
- W2259664588 countsByYear W22596645882020 @default.
- W2259664588 countsByYear W22596645882021 @default.
- W2259664588 countsByYear W22596645882022 @default.
- W2259664588 countsByYear W22596645882023 @default.
- W2259664588 crossrefType "journal-article" @default.
- W2259664588 hasAuthorship W2259664588A5012009078 @default.
- W2259664588 hasAuthorship W2259664588A5026919394 @default.
- W2259664588 hasAuthorship W2259664588A5038776482 @default.
- W2259664588 hasAuthorship W2259664588A5049445988 @default.
- W2259664588 hasAuthorship W2259664588A5058867402 @default.
- W2259664588 hasAuthorship W2259664588A5061175474 @default.
- W2259664588 hasBestOaLocation W22596645881 @default.
- W2259664588 hasConcept C104317684 @default.
- W2259664588 hasConcept C136449434 @default.
- W2259664588 hasConcept C140704245 @default.
- W2259664588 hasConcept C142724271 @default.
- W2259664588 hasConcept C145059251 @default.
- W2259664588 hasConcept C159047783 @default.
- W2259664588 hasConcept C203014093 @default.
- W2259664588 hasConcept C2522874641 @default.
- W2259664588 hasConcept C2775996393 @default.
- W2259664588 hasConcept C2776178377 @default.
- W2259664588 hasConcept C2776460866 @default.
- W2259664588 hasConcept C2779134260 @default.
- W2259664588 hasConcept C2779656172 @default.
- W2259664588 hasConcept C2779819720 @default.
- W2259664588 hasConcept C3008058167 @default.
- W2259664588 hasConcept C524204448 @default.
- W2259664588 hasConcept C54355233 @default.
- W2259664588 hasConcept C71924100 @default.
- W2259664588 hasConcept C86803240 @default.
- W2259664588 hasConcept C8891405 @default.
- W2259664588 hasConceptScore W2259664588C104317684 @default.
- W2259664588 hasConceptScore W2259664588C136449434 @default.
- W2259664588 hasConceptScore W2259664588C140704245 @default.
- W2259664588 hasConceptScore W2259664588C142724271 @default.