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- W2259715377 abstract "l> 800x600 l> Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 l> ject classid=clsid:38481807-CA0E-42D2-BF39-B33AF135CC4D id=ieooui> st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable{mso-style-name:Table Normal;mso-tstyle-rowband-size:0;mso-tstyle-colband-size:0;mso-style-noshow:yes;mso-style-priority:99;mso-style-parent:;mso-padding-alt:0in 5.4pt 0in 5.4pt;mso-para-margin:0in;mso-para-margin-bottom:.0001pt;mso-pagination:widow-orphan;font-size:10.0pt;font-family:Times New Roman,serif;} Background : Tuberculosis with high prevalence in HIV/AIDSpatients is the main reason for morbidity and mortality in these patients.About one-third of patients with HIV infectionhave concomitant tuberculosis. Lack of appropriate infection control on manysocial and economic communities will impose. Comprehensive study on the effectsof anti-tuberculosis drugs in patients with HIV infectingless done, also due to the importance of reducing morbidity and mortality,reduce the cost of disease, identifying drug pharmacokinetics, the importanceof completing treatment tuberculosis, this study was performed to evaluate theeffects of anti- tuberculosis drugs on HIV infectionand to identify the drug pharmacokinetics and so more complete tuberculosistreatment. Methods : A historical cohort study was performed onpatients referring to the research center for HIV/AIDS,consultation center, department of infection diseases of ImamKhomeini Hospitalin Tehran, Iran. Atotal number of 75 cases with HIVnegative versus HIV positive patientswith pulmonary tuberculosis and positive sputum smear in accordance withinclusion and exclusion criteria were selected. Results : In this study, the frequency of peripheral neuropathy 27(73%),arthralgia 31(83.8%), vomiting 18(48.6%),headache 26(70.3%), dizziness 20(54.1%),renal toxicity 4(10.8%) and of skin rash 10(27%)in patients with HIV virus infection weresignificantly more than HIV- negative patients.Hepatotoxicity, fever and anemia were not significantly more common in patientswho infected with HIV virus. Conclusion: The HIV patients, who have not received antiretroviraldrugs during tuberculosis treatment, may show higher incidence ofanti-tuberculosis drugs complications." @default.
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- W2259715377 date "2011-01-01" @default.
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- W2259715377 title "Drug-induced complications of anti-tuberculosis drugs in HIV patients" @default.
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